Syllabus database for doctoral courses
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Syllabus database for doctoral courses
SYLLABI FOR DOCTORAL COURSES
| Swedish title | Specifikation av stamceller; från könsceller till neuronala celler |
|---|---|
| English title | Specification of stem cells; from germ cells to neuronal cells |
| Course number | 2914 |
| Credits | 1.5 |
| Responsible KI department | Institutionen för cell- och molekylärbiologi |
| Specific entry requirements | |
| Grading | Passed /Not passed |
| Established by | The Board of Doctoral Education |
| Established | 2016-03-22 |
| Purpose of the course | To increase the understanding of the mechanisms involved in the specification of stem cells from germ cells to neuronal cells. |
| Intended learning outcomes | Upon completion of the course, the doctoral students can describe pluripotent stem cell, somatic and germ cell specification during development. The doctoral students can compare different strategies of cell differentiation and evaluate several methodologies in order to critically apply them to their research. |
| Contents of the course | The course covers the developmental principles of pluripotent cell regulation and their specification into germ or somatic cells. Disregulation of these events and subsequent disease modelling will also be discussed. Germ layer specification will be addressed with a specific focus on ectoderm patterning, neuronal fate specification, generation of organoids in vitro and proliferation control of neurogenesis. Cutting-edge-techniques like single-cell RNA sequencing, lineage tracing methods and in vitro stem cell differentiation will be presented. In the first part of the course, participants will achieve a theoretical understanding of early embryonic development after fertilization to derive two broad cell types, i.e somatic versus germ cells. In this first part of the course, the main focus will be on germ cells. In the second part, students will gain general knowledge on stem cell differentiation into neuronal subtypes with their application in disease modelling in vitro. |
| Teaching and learning activities | The learning modes used in the course includes daily class room lectures, discussions, microscope sessions and demonstrations of a single cell RNA sequencing facility. The students will prepare group presentations on pre-selected topics, which will be presented the last day of the course and constitutes the examination. |
| Compulsory elements | Atttendance to all lectures, microscope sessions and visit to the single cell RNA sequecing facility is required. It is obligatory to hold a group presentation on the last day of the course as well as to attend the other group presentations as a peer reviewer. Absence can be compensated for by a written report using literature in agreement with the course director. |
| Examination | The examination will be held on the last day of the course and will consist of i) participation in a group presentation of a selected topic in neurodegenerative disease/stem cell modeling of neurodegenerative diseases, ii) act as a peer-reviewing audience when other groups are presenting. All the learning outcomes will be individually assessed. |
| Literature and other teaching material | Recent articles on the themes of the course. | Course responsible |
Matti Nikkola Institutionen för cell- och molekylärbiologi Matti.Nikkola@ki.se |
| Contact person |
Linda Lindell Institutionen för cell- och molekylärbiologi 08-524 872 90 0703822909 linda.lindell@ki.se Solnavägen 9 171 77 Stockholm |
