Syllabus database for doctoral courses
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Syllabus database for doctoral courses
SYLLABI FOR DOCTORAL COURSES
| Swedish title | Applikation av molekylärbiologiska och imaging tekniker vid neurodegenerativa sjukdomar |
|---|---|
| English title | Application of molecular biology and molecular brain imaging techniques in neurodegenerative disorders |
| Course number | 2315 |
| Credits | 3.0 |
| Responsible KI department | Institutionen för neurobiologi, vårdvetenskap och samhälle |
| Specific entry requirements | Nej |
| Grading | Passed /Not passed |
| Established by | The Board of Doctoral Education |
| Established | 2015-09-17 |
| Purpose of the course | |
| Intended learning outcomes | After the course the students will understand the main pathophysiological features of neurodegenerative diseases, with a focus on dementia disorders. After the course a doctoral student shall be able to: - Account for recent advances in CSF and in vivo brain imaging biomarkers - Account for the theoretical basis of main techniques used in molecular imaging and biochemical analyses used on living subjects and biological materials - Develop, evaluate and validate in vivo brain and CSF markers - Perform key in vitro and in vivo techniques - Collect, process, analyze and interpret data of key techniques - Apply what they have learned to their own research work |
| Contents of the course | This course will focus on scientific approaches used to study neurodegenerative disorders. Topics for the practical experiments will include the following: demonstrations of molecular imaging techniques that are used to study function and pathological changes in the brain of living patients/animal models including PET/micro-PET, demonstrations of MRI techniques for structural brain analysis, histopathological examination of brain lesions in human post-mortem brain tissue and autoradiography and radio-ligand binding techniques to study localization of receptors, binding potential, changes in neurotransmitter function and to correlate these with other pathological changes in the brain, quantitative assays of biomarkers and proteins involved in signaling pathways in biological fluids and in the brain using brain homogenate, human CSF and/or plasma etc. The course will also discuss, provide a deep understanding, some hands-on training on how to setup and use common in-house sensitive assays, their advantages, applicability and caveats. |
| Teaching and learning activities | The course is full time (10 days) and will be organised as an integration of lectures, combined with practical laborations, demonstrations and literature studies. |
| Compulsory elements | All parts of the course are mandatory. Absence from any of these will be compensated for by extra individual assignments provided by the course organizers. |
| Examination | All the intended learning outcomes will be assessed by a combination of written examination, written reports for the practical workshops, and oral presentation. |
| Literature and other teaching material | Students will receive specific literature to prepare for practical experiments and for the final examination. The literature will be selected journal articles and lab handouts. | Course responsible |
Taher Darreh-Shori Institutionen för neurobiologi, vårdvetenskap och samhälle Taher.Darreh-Shori@ki.se |
| Contact person |
Elena Rodriguez-Vieitez Institutionen för neurobiologi, vårdvetenskap och samhälle elena.rodriguez-vieitez@ki.se |
