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SYLLABI FOR DOCTORAL COURSES

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Swedish title Hjärntumörer
English title Brain tumors
Course number 2720
Credits 1.5
Responsible KI department Institutionen för onkologi-patologi
Specific entry requirements
Grading Passed /Not passed
Established by The Board of Doctoral Education
Established 2015-09-01
Purpose of the course
Intended learning outcomes After successfully completing this course you as a student are expected to be able to: Describe the basic organization of the human CNS and its main cell types. Describe and recognize the main features of brain tumors, recognize that the spectrum of brain tumors is different in adult and children. Explain the concept of brain tumor stem cells. Explain why brain tumors are so difficult to treat. Critically discuss and evaluate literature concerning brain tumors.
Contents of the course The course is about brain tumors and their pathology, biology and genetics. A brief review of basic anatomy and the main cell types of CNS with focus on neural stem cells will be given. Mechanisms of brain tumor development is the main part of the course. Classification of brain tumors, risk factors and molecular genetics will also be covered. Clinical aspects of brain tumors will be presented in the form of demonstrations. Invited speakers will introduce the research front with special focus on brain tumor stem cells, brain tumor models in mice, novel technologies and targeted therapies.
Teaching and learning activities The course will be given in the form of lectures, group seminars, demonstrations, and site visits. The aim of the lectures is to support students in gathering the basic as well as more in-depth knowledge about brain tumors. The aim of the group seminars is to support the capacity of the students to critically discuss and evaluate literature relevant to the course. Demonstrations of instrumentation and site visits will help to visualize the current situation in brain tumor research and clinical settings.
Compulsory elements All course activities are compulsory. Absence is compensated for according to instructions from the course leader.
Examination To pass the course, the student has to show that the learning outcomes have been achieved through a compulsory home exam.
Literature and other teaching material A course binder will be distributed that contains a handful of review articles on the topics covered during the course.
Including:
Emerging insights into the molecular and cellular basis of glioblastoma. Dunn GP, et al., Genes Dev. 2012 Apr 15;26(8):756-84.
Targeting brain cancer: advances in the molecular pathology of malignant glioma and medulloblastoma. Huse JT, Holland EC. Nat Rev Cancer. 2010 May;10(5):319-31.
The somatic genomic landscape of glioblastoma. Brennan CW, et. al. Cell. 2013 Oct 10;155(2):462-77
Comprehensive genomic characterization defines human glioblastoma genes and core pathways. Cancer Genome Atlas Research Network. Nature. 2008 Oct 23;455(7216):1061-8.
Identification of human brain tumour initiating cells. Singh SK, et al. Nature. 2004 Nov 18;432(7015):396-401.
ZFHX4 Interacts with the NuRD Core Member CHD4 and Regulates the Glioblastoma Tumor-Initiating Cell State. Chudnovsky Y, et al. Cell Rep. 2014 Jan 30;6(2):313-24.
Dissecting the genomic complexity underlying medulloblastoma. Jones DT. Nature. 2012 Aug 2;488(7409):100-5.
Selected chapters from WHO Classificatin of Tumours of the Central Nervous System.
Course responsible Monica Nister
Institutionen för onkologi-patologi
08-517 70309
070-2681630
Monica.Nister@ki.se
Contact person Daniel Hägerstrand
Institutionen för onkologi-patologi
08-517 705 85
070-569 87 36
daniel.hagerstrand@ki.se

CCK R8:05

171 76
Stockholm