Kursplansdatabas för forskarutbildningskurser

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Svensk benämning Cancercellens energimetabolism
Engelsk benämning Cancer cell energy metabolism
Kursnummer 2515
Antal högskolepoäng 1.5
Kursansvarig institution Institutionen för onkologi-patologi
Särskild behörighet
Betygsskala Godkänd/Icke godkänd
Fastställd av The Board of Doctoral Education
Datum för fastställande 2015-03-04
Kursens syfte
Kursens lärandemål After the course, the student should be able to:
- describe and explain the role of altered cellular metabolism in cancer development and cancer progression;
- reflect upon the interaction between oncogenic signaling and tumor metabolism;
- discuss how tumor metabolism may be exploited in anticancer therapies and diagnosis/prognosis.

Kursens innehåll The course provides an introduction to cancer cell metabolism. Focus is on the roles of oncogenic signaling and tumor microenvironment as drivers of tumor development and progression. Therapeutic and diagnostic perspectives exploiting the altered cancer metabolism are discussed.
Arbetsformer The course consists mainly of lectures, but also a minisymposium with invited international speakers and group discussions/seminars.
Examination Examination is divided into two parts: Firstly, during active participation in the Meet the scientists seminar and in connection with the beehive group preparing that. Secondly, the students will be given an individual written assignment to be delivered within two weeks after the end of the course. This assignment is a short project proposal within one topic chosen from a list of 10. The proposal will contain an overview of the field which motivates a specific research question identified by the student and a brief work plan that explains how the question/hypothesis can be solved/investigated.
Kurslitteratur och övriga läromedel This is a list of suggested literature Cairns RA, Harris IS, Mak T. Regulation of cancer cell metabolism. Nat Rev Cancer 2011 Schulze A and Harris AL. How cancer metabolism is tuned for proliferation and vulnerable to disruption. Nature 2012 Ward PS, Thompson CB. Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate. Cancer Cell 2012 Galluzzi L, Kepp O, Vander Heiden MG, Kroemer G. Metabolic targets for cancer therapy. Nat Rev Drug Discov 2013 Parks SK, Chiche J, Pouyssegur J. Disrupting proton dynamics and energy metabolism for cancer therapy. Nat Rev Cancer 2013
Obligatoriska moment Attendance at lectures is strongly advised. Participation in the beehive and Meet the scientist session is mandatory. To compensate for absence due to e.g. illness the student may be required to write a report and/or discuss the missed subject with the course leaders.
Kursansvarig Angelo De Milito
Institutionen för onkologi-patologi

Forskningsringen 50

Kontaktpersoner Mimmi Shoshan
Institutionen för onkologi-patologi
08-517 754 60