Syllabus database for doctoral courses

  • Syllabus database for doctoral courses


Swedish title Cancercellens energimetabolism
English title Cancer cell energy metabolism
Course number 2515
Credits 1.5
Responsible KI department Institutionen för onkologi-patologi
Specific entry requirements
Grading Passed /Not passed
Established by The Board of Doctoral Education
Established 2015-03-04
Purpose of the course
Intended learning outcomes After the course, the student should be able to:
- describe and explain the role of altered cellular metabolism in cancer development and cancer progression;
- reflect upon the interaction between oncogenic signaling and tumor metabolism;
- discuss how tumor metabolism may be exploited in anticancer therapies and diagnosis/prognosis.

Contents of the course The course provides an introduction to cancer cell metabolism. Focus is on the roles of oncogenic signaling and tumor microenvironment as drivers of tumor development and progression. Therapeutic and diagnostic perspectives exploiting the altered cancer metabolism are discussed.
Teaching and learning activities The course consists mainly of lectures, but also a minisymposium with invited international speakers and group discussions/seminars.
Examination Examination is divided into two parts: Firstly, during active participation in the Meet the scientists seminar and in connection with the beehive group preparing that. Secondly, the students will be given an individual written assignment to be delivered within two weeks after the end of the course. This assignment is a short project proposal within one topic chosen from a list of 10. The proposal will contain an overview of the field which motivates a specific research question identified by the student and a brief work plan that explains how the question/hypothesis can be solved/investigated.
Literature and other teaching material This is a list of suggested literature Cairns RA, Harris IS, Mak T. Regulation of cancer cell metabolism. Nat Rev Cancer 2011 Schulze A and Harris AL. How cancer metabolism is tuned for proliferation and vulnerable to disruption. Nature 2012 Ward PS, Thompson CB. Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate. Cancer Cell 2012 Galluzzi L, Kepp O, Vander Heiden MG, Kroemer G. Metabolic targets for cancer therapy. Nat Rev Drug Discov 2013 Parks SK, Chiche J, Pouyssegur J. Disrupting proton dynamics and energy metabolism for cancer therapy. Nat Rev Cancer 2013
Compulsory elements Attendance at lectures is strongly advised. Participation in the beehive and Meet the scientist session is mandatory. To compensate for absence due to e.g. illness the student may be required to write a report and/or discuss the missed subject with the course leaders.
Course responsible Angelo De Milito
Institutionen för onkologi-patologi

Forskningsringen 50

Contact person Mimmi Shoshan
Institutionen för onkologi-patologi
08-517 754 60