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Swedish title Klinisk och experimentell neuroimmunologi
English title Clinical and experimental neuroimmunology
Course number 1627
Credits 1.5
Responsible KI department Institutionen för klinisk neurovetenskap
Specific entry requirements
Grading Passed /Not passed
Established by The Board of Doctoral Education
Established 2015-03-10
Purpose of the course
Intended learning outcomes After this course the students should be able to: (i) describe the basic clinical characteristics of the major neuroinflammatory diseases; (ii) design experiments using animal models for neuroinflammatory diseases in rats and mice, compare models and discuss their advantages and limitations, (iii) evaluate and interpret new findings and recent scientific papers in the field and (iv) speculate on molecular mechanisms underlying neuroinflammatory disease and hypothesize how knowledge on these mechanisms can enable therapy and prevention.
Contents of the course The course includes the overview of clinical symptoms, signs, pathology, treatments and diagnostic criteria for the most important neuroimmunological conditions including Multiple Sclerosis, Myasthenia Gravis, Guillain-Barré Syndrome, Alzheimer¿s disease as well as infections, trauma, tumors and pain. Also included is an overview of experimental models of neuroimmunological diseases, with an emphasis on techniques for genetic analysis (intercrosses, congenics, transgenics etc). Key molecular concepts in neuroinflammation are covered such as immune mechanisms of disease as well as tissue degeneration/regeneration. Different techniques used to study neuroinflammation are discussed such as imaging and flow cytometry.
Teaching and learning activities The course combines: (i) traditional lectures given by experts in the field, consisting of a mixture of both clinicians as well as basic researchers covering diseases, technological aspects or basic processes in neuroimmunology; (ii) an individual assignment followed by an interactive presentation/discussion on the last day. The assignment will consist of a presentation of a high-impact scientific paper relevant to the student¿s own research topic and that is of importance for the neuroimmunology field.
Examination Examination will be based on the presentation of the own individual assignment and the subsequent discussion during the last day of the course (please see "Teaching and learning activities") and the feedback given to other students on their assignments. In their presentation, students should be able to comment on their article of choice in the context of the items described above under "learning outcomes". Guidelines for the preparation of the assignment will be sent out to the students two weeks before the start of the course.
Literature and other teaching material Course litterature will consist of lecture handouts and current scientific papers (and reviews) handed out during the course.
Compulsory elements All lectures and individual presentations are compulsory. Compensation for absence can be discussed with the course directors.
Course responsible Xingmei Zhang
Institutionen för klinisk neurovetenskap


Xingmei.Zhang@ki.se

CMM


Stockholm
Contact person Andre Ortlieb
Institutionen för klinisk neurovetenskap


Andre.Ortlieb@ki.se

Pernilla Strid
Institutionen för klinisk neurovetenskap


Pernilla.Strid@ki.se

Maja Jagodic
Institutionen för klinisk neurovetenskap
+46851776258
+46739801889
Maja.Jagodic@ki.se

Neuroimmunology Unit, CMM, L8:04

17176
Stockholm