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SYLLABI FOR DOCTORAL COURSES

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Swedish title Den tredje dimensionen av cellkärnans funktioner
English title The third dimension of nuclear functions
Course number 2841
Credits 1.5
Responsible KI department Institutionen för mikrobiologi, tumör- och cellbiologi
Specific entry requirements ingen särskild behörighet efterfrågas
Grading Passed /Not passed
Established by The Board of Doctoral Education
Established 2015-03-04
Purpose of the course
Intended learning outcomes Following the completion of the course the students will be able to describe the basic principles of 3D genome organisation and how this relates to nuclear functions such as transcription, replication, DNA repair and telomere maintenance. The students will also be able to design experiments for studying the 3D structure of chromatin, compartmentalisation of nuclear functions in the nuclear space and to critically evaluate results obtained with these techniques.
Contents of the course The course covers the basic principles of genome regulation in 3D and how marks of the primary chromatin fibre relate to the 3D structure of chromatin. Particular attention will be paid to the regulation the nuclear architecture during development, and its role in lineage specification by means of coordination of transcription and replication in space and time. Speakers will include the course organizers and several well-known international researchers dedicated to research on relevant aspects of chromatin.
Teaching and learning activities The learning activities used in the course include lectures, research seminars and research article presentation by the students. Each student will present a recent publication in the form of a journal club. Students will also be encouraged to actively participate in the course. There will be substantial time for discussions after the lectures and research seminars.
Compulsory elements The lectures, seminars and journal club presentations are compulsory. Compensation according to the instructions of the course director.
Examination Examination is based on the journal club presentation and a written test. Every student will present a pre-selected article, and will be the opponent for the presentation of a fellow student. The student's performance at these two occasions combined with the test results will be the basis for the final assessment.
Literature and other teaching material The Cell: A Molecular Approach. Cooper GM., Hausman RE. Latest edition.

Latest literature in the field of the third dimension of nuclear functions as reference literature.
Course responsible Anita Göndör
Institutionen för onkologi-patologi
08 524 862 03

anita.gondor@ki.se

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