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SYLLABI FOR DOCTORAL COURSES

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Swedish title Motorneuronsjukdomar och frontotemporal demens: praktiska tillämpningar i human neuropatologi och stamcellsmodellering
English title Motor neuron diseases and frontotemporal dementia: Practical applications of human neuropathology and stem cell modeling
Course number 2823
Credits 1.5
Responsible KI department Institutionen för neurovetenskap
Specific entry requirements Documented knowledge in neuroscience (for example from MSc course).
Grading Passed /Not passed
Established by The Board of Doctoral Education
Established 2014-10-03
Purpose of the course
Intended learning outcomes I) The students will have an understanding of how stem cells can be used to model and study neurodegenerative diseases, with of a focus on motorneuron diseases. They will also get practical skills and apply their theoretical knowledge into deriving neuronal progenitors and postmitotic motor neurons from stem cells.

II) Through practical microscope session, studying the human nervous system in health and disease, the students will learn to identify pathological features of motor neuron diseases and FTD as well as typical examples of other neurodegenerative diseases.

III) The students will acquire in depth knowledge and understanding of selected neurodegenerative diseases with a focus on amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD) and spinal muscular atrophy (SMA). They will be able to understand and describe their clinical presentations and causes, when known. The students will learn about multiple aspects of these neurodegenerative diseases, including disease modeling in fly, fish and mice.
Contents of the course i) the majority of the lectures will be held by invited researchers with expertize in motor neuron diseases and FTD allowing the students to get an international perspective of these research areas.
ii) The course will include presentations on stem cells and their derivation into neurons and use in disease modeling in vitro.
iii) The course includes a practical stem cell laboratory where mouse embryonic stem cells will be differentiated into motor neurons.
iv) The course will encompass practical microscope sessions with analysis of the human nervous system in health and disease, enabling students to learn to identify pathological features associated with neurodegenerative diseases.
v) The course will include lectures on the clinical presentations of several neurodegenerative diseases, with a focus on amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD) and spinal muscular atrophy (SMA).
vi) The course will go through multiple aspects of these neurodegenerative diseases.
Teaching and learning activities Daily class room lectures. Microscope sessions. Stem cell lab class.
The students will prepare a group presentation of a pre-selected topic, which will be presented the last day of the course and constitutes the examination.
Compulsory elements At least 80% attendance at lectures is required. 100% attendance of microscope sessions and the stem cell laboratory class is required. It is obligatory to hold a group presentation on the last day of the course as well as to attend the other group presentations as a peer reviewer. In the case of absence the session might be compensated by a written report using literature of agreement with the course director.
Examination The examination will be held on the last day of the course and will consist of i) participation in a group presentation of a selected topic in neurodegenerative disease/stem cell modeling of neurodegenerative diseases, ii) act as a peer-reviewing audience when other groups are presenting, iii) an individual assessment of the intended learning outcomes through a written multiple-choice test.
Literature and other teaching material The lecturers and course organizers will provide a list and PDFs of recommended scientific articles published in scientific journals as well as recommended weblinks and protocols for the stem cell laboratory.
Course responsible Eva Hedlund
Institutionen för neurovetenskap


eva.hedlund@ki.se

Retzius v. 8

17177
Stockholm
Contact person Caroline Graff
Institutionen för neurobiologi, vårdvetenskap och samhälle
733839399
0733839399
Caroline.Graff@ki.se

Bioclinicum J10:20
Visionsgatan4
17164
Solna