Syllabus database for doctoral courses
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Syllabus database for doctoral courses
SYLLABI FOR DOCTORAL COURSES
| Swedish title | Kliniska applikationer inom muskoskeletal regenerativ medicin |
|---|---|
| English title | Clinical Applications in Musculoskeletal Regenerative Medicine |
| Course number | 2818 |
| Credits | 1.5 |
| Responsible KI department | Institutionen för klinisk vetenskap, intervention och teknik |
| Specific entry requirements | none |
| Grading | Passed /Not passed |
| Established by | The Board of Doctoral Education |
| Established | 2014-10-03 |
| Purpose of the course | |
| Intended learning outcomes | At the end of the course, the doctoral student will be able to describe: 1) basics of stem cell biology, stem cell differentiation, and the stem cell niche, 2) a number of novel technologies and approaches in stem cell research and regenerative medicine, 3) strategies for safe and effective translation of basic stem cell biology into the clinic. The student can demonstrate an interdisciplinary understanding of central concepts in stem cell science and critically evaluate different methods and techniques used. The student will be able to extract and integrate information from state-of-the-art lectures in combination with overview articles and literature searches on the internet within the research field. |
| Contents of the course | The course covers key concepts in translational research on stem cells and the stem cell niche from the laboratory to the patient in the clinic. This includes a general overview of stem cell biology and history, sources, homing and circulation and interaction with the immune system, and clinical applications. Invited speakers will give advanced summaries of the latest research in the stem cell and regenerative medicine field. |
| Teaching and learning activities | The pedagogic framing of this course is based on lectures with corresponding research topics. The student will be welcomed to take an active part, contribute and value discussions on relevant topics in the stem cell field. Networking with students and speakers is highly encouraged in this course. |
| Compulsory elements | The lectures and examination are mandatory. Compensation according to the instructions of the course director. |
| Examination | Individual written project report will be performed and handed in at the end of the course. Formative assessment of each student in connection with discussions with lectures and peers. |
| Literature and other teaching material | The course literature will consist of recent original and review papers on selected topics within the field of stem cells and the stem cell niche as well as the latest articles from the speakers¿ lecturers. Handouts from the lecturers will also be included. Examples of review articles: - Viviane Tabar & Lorenz Studer. Pluripotent stem cells in regenerative medicine: challenges and recent progress. Nature Reviews Genetics. 2014; 15, 82-92 - Avital Mendelson & Paul S Frenette. Hematopoietic stem cell niche maintenance during homeostasis and regeneration. Nature Medicine. 2014; 20, 833-846 - Stefanie Dimmeler, Sheng Ding, Thomas A Rando & Alan Trounson. Translational strategies and challenges in regenerative medicine. Nature Medicine. 2014; 20, 814-821 - Ilic D. Stem cell based therapy-where are we going? Lancet. 2012; 379(9819):877-8. - Trounson A. Clinical trials for stem cell therapies. BMC Med. 2011; 9:52. - Chien, K.R. Regenerative medicine and human models of human disease. Nature. 2008; 453(7193):302-5. - Ankrum J. Mesenchymal stem cell therapy: Two steps forward, one step back. Trends Mol Med. 2010; (5):203-9. Keating A. Mesenchymal stromal cells: new directions. Cell Stem Cell. 2012; 10(6):709-16. - Le Blanc K. Multipotent mesenchymal stromal cells and the innate immune system. Nat Rev Immunol. 2012; 12(5):383-96. Examples of webpages: http://stemcells.nih.gov/ http://www.explorestemcells.co.uk/ |
Course responsible |
Ju Luan Institutionen för klinisk vetenskap, intervention och teknik 076-425 2024 ju.luan@ki.se |
| Contact person |
Cecilia Gotherstrom Institutionen för klinisk vetenskap, intervention och teknik 08-58581487 070-4712300 Cecilia.Gotherstrom@ki.se Klinisk Immunologi F79 Karolinska Universitetssjukhuset Huddinge 14186 Stockholm |
