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Swedish title Pulmonell inflammation
English title Pulmonary inflammation
Course number 2535
Credits 3.0
Responsible KI department Institutet för miljömedicin
Specific entry requirements ---
Grading Passed /Not passed
Established by The Board of Doctoral Education
Established 2014-03-17
Purpose of the course
Intended learning outcomes After the course the student should be able to show an understanding of the most important principles of lung physiology and mechanisms behind the respiratory impairment in asthma, chronic obstructive pulmonary disease (COPD), interstitial lung diseases, invasive lung infections and animal models used in respiratory research. The student should also be able to discuss the methods used for the diagnostics of the different lung diseases. Furthermore, the student should be acquainted with the research front-line in each of the lung diseases and the different models used in the research as well as be able to understand and evaluate scientific papers regarding lung diseases.
Contents of the course The principles and challenges of important inflammatory diseases of the lungs from a translational perspective, that is from clinical practice to experimental research. The course will be interactive between both the participants and the lecturers. The course is focused on the following topics: asthma, chronic obstructive pulmonary disease (COPD), interstitial lung diseases, invasive lung infections and animal modesl used in respiratory research. Lectures cover epidemiology, symptoms and differential diagnosis, diagnostic methods, pathogenic mechanisms, treatment (existing, future). Demonstrations cover methods that are used for diagnostic and/or research purposes: inhalation provocation, allergy diagnosis, spirometry, peak expiratory flow (PEF) measurements, chest X-ray, computer tomography, other imaging methods, bronchoscopy/broncholaveolar lavage, flow cytometry etc. For all the diseases specific lectures will cover how the research in each field has evolved, were the front-line is today and specifically how different animal models can be used for reaching further knowledge.
Teaching and learning activities The course, given during two separate weeks, comprises seven days of scheduled studies and three days of self-studies for literature review, group case work and preparation for the web-based examination.
The general format is as follows: Each day starts with a case presentation and discussion in groups, when the group consisting of students with different backgrounds have a short brainstorming how to solve the case with regard to cause of disease, diagnostics, treatments and research. This is followed by lectures before lunch. After lunch there will be demonstrations and further lectures, and the day concludes with group discussions about the cases. In addition, each group is assigned one case that they will study more in depth during the interval before the second part of the course, and meet with the group to discuss before they present it to the whole class for open discussion on the last day.
The case work may include studying aspects of the disease not covered by the lectures/demonstrations, suggesting novel treatments and how they could be evaluated, identify areas where more research into mechanisms is needed and propose hypotheses and how these can be tested in a patient or animal model setting.
Compulsory elements Project work and attendance at the project presentation and demonstrations is compulsory. In case of absence, a written report that cover the part that was lost can be requested.
Examination Web-based written examination. Oral presentations of small-group project work. At this occasion special attention is given to that all students are actively contributing.
Literature and other teaching material Selected and up-to-date scientific review papers will be handed out during the course
Course responsible Mikael Adner
Institutet för miljömedicin


mikael.adner@ki.se

Contact person Jan Wahlström
Institutionen för medicin, Solna
08-51770663
070-7180301
Jan.Wahlstrom@ki.se

Lungforskningslab L4:01
Karolinska Universitetssjukhuset, Solna
171 76
Stockholm