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SYLLABI FOR DOCTORAL COURSES

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Swedish title Musmodeller av human cancer
English title Mouse models of human cancer
Course number 2367
Credits 1.5
Responsible KI department Institutionen för klinisk vetenskap, intervention och teknik
Specific entry requirements
Grading Passed /Not passed
Established by The Board of Doctoral Education
Established 2014-03-10
Purpose of the course
Intended learning outcomes The aim of the course is to convey an enhanced knowledge about the generation and use of mouse models in cancer research, as well as to empower the student to make an informed decision of suitable models for his/her own research situation.

After completion of the course, the student should be able to:
- Compare and contrast different categories of mouse models of cancer and analyze the pros and cons of models within each category
- Apply state-of-the-art technology in the generation and use of mouse models of cancer
- Relate the knowledge about mouse models of cancer to his/her own research
- Independently be able to search for more information about mouse models of cancer
Contents of the course The course will provide an introduction to the generation and use of mouse models of human cancer. A survey of the state-of-the-art technology in the field, such as conditionality, inducibility and multimodal life-imaging, will be provided as well as a short introduction into mouse pathology. Also, the use of mouse models in various applications related to cancer research, such as studies of metastasis or experimental therapy/preclinical testing, will be reviewed. Mouse models of particular interest will be highlighted. In parallel, literature studies of mouse models of specific indications will be performed by the students, with the aim of designing new and improved mouse models.
Teaching and learning activities 1. Lectures will provide knowledge about the current state of the field.
2. Case in point seminars will highlight mouse models of cancer of particular importance.
3. Group assignments will be used to perform a literature review and gain insight into disease-specific mouse models of cancer.
Compulsory elements Attendance is compulsory during all lectures and scheduled time slots for the group assignment. Absence has to be compensated for in accordance with the course organizer.
Examination Course examination is composed of two parts:
1. Oral exam, consisting of a powerpoint presentation and discussion of the group assignments, in which the students will present the design of a new and improved mouse model of human cancer.
2. Handing in of powerpoint presentation with corrections based on oral exam.
Literature and other teaching material The selection of literature is made in such a way as to aid the student in fulfilling the learning outcomes of the course. Literature in the form of current review articles on relevant topics, as well as original research papers describing illustrative examples of the use of mouse models of cancer will be provided during the course.
Course responsible Rainer Heuchel
Institutionen för klinisk vetenskap, intervention och teknik
08 585 830 33

rainer.heuchel@ki.se
Contact person