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SYLLABI FOR DOCTORAL COURSES

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Swedish title Hematopoes och hematopoetiska stamceller vid hälsa och sjukdom
English title Hematopoiesis and hematopoietic stem cells in health and disease
Course number 2717
Credits 2.0
Responsible KI department Institutionen för medicin, Huddinge
Specific entry requirements None
Grading Passed /Not passed
Established by The Board of Doctoral Education
Established 2013-03-07
Purpose of the course
Intended learning outcomes After the completed course, the student will be able to describe the basics of hematopoietic stem cell development, stem cell transplantation, development of different types of leukemia and a number of novel technologies and approaches for hematopoietic stem cell research and clinical treatment. The student will be able to demonstrate an interdisciplinary understanding of central concepts in hematopoietic stem/progenitor cells, regulation of hematopoiesis, engraftment and immunological aspects of stem cell transplantion and critically evaluate different methods and techniques used. The student will be able to extract and integrate information from state-of-the-art lectures in combination with overview articles and literature searches on the internet within the research field.
Contents of the course The course covers key concepts in hematology from the laboratory to the patient in the clinic. This includes visits to hematology clinic including bone marrow sampling and ward round as well as laboratory demonstration. There will be a general overview of hematology including development of fetal and adult hematopoiesis, molecular regulation of hematopoiesis, leukemic stem cells, immunological consideration in stem cell transplantation, future treatment, stem cell homing and summary of the latest events in the normal development of hematopoiesis as well as development and treatment of hematological disorders including myeloid and lymphoid leukemia. The student will be required to take an active part, contribute and value discussions on stem cell transplantation.
Teaching and learning activities The pedagogic framing of this course is based on lectures with corresponding review papers. The course includes workshops with illustrative predicaments where the students are required to take an active part in the discussions. Group discussions/workshop will be conducted where the students discuss and integrate information from the lectures and review papers. The students prepare and present their examination task in a written report that is handed in after the course.
Compulsory elements The lectures and discussions are mandatory. Compensation according to the instructions of the course director.
Examination Individual written project report that will be performed and handed in at the end of the course. The individual performance of each student will be evaluated separately.
Literature and other teaching material The course literature will consist of recent review papers on selected topics within the field of stem cell transplantation as well as the latest articles from the expert lecturers. Handouts from the lecturers will also be included.

Examples of review articles:

1. T. Suda, K. Takubo, G. L. Semenza, Metabolic regulation of hematopoietic stem cells in the hypoxic niche. Cell Stem Cell 9, 298 (Oct 4, 2011).
2. M. Askmyr, J. Quach, L. E. Purton, Effects of the bone marrow microenvironment on hematopoietic malignancy. Bone 48, 115 (Jan 1, 2010).
3. G. B. Adams, Deconstructing the hematopoietic stem cell niche: revealing the therapeutic potential. Regen Med 3, 523 (Jul, 2008).
4. S. Mendez-Ferrer, P. S. Frenette, Hematopoietic stem cell trafficking: regulated adhesion and attraction to bone marrow microenvironment. Ann N Y Acad Sci 1116, 392 (Nov, 2007).
5. M. J. Kiel, S. J. Morrison, Maintaining hematopoietic stem cells in the vascular niche. 25, 862 (Dec, 2006).
6. K. Kaushansky, Hematopoietic growth factors, signaling and the chronic myeloproliferative disorders. Cytokine Growth Factor Rev 17, 423 (Dec, 2006).
7. A. Nakamura-Ishizu, T. Suda, Hematopoietic stem cell niche: An interplay among a repertoire of multiple functional niches. Biochimica et biophysica acta, (Sep 4, 2012).
8. H. Ema, T. Suda, Two anatomically distinct niches regulate stem cell activity. Blood 120, 2174 (Sep 13, 2012).
9. Audrito, V., Vaisitti, T., Serra, S., Bologna, C., Brusa, D., Malavasi, F., and Deaglio, S. (2013). Targeting the microenvironment in chronic lymphocytic leukemia offers novel therapeutic options. Cancer letters 328, 27-35.
10. Damm, F., Nguyen-Khac, F., Fontenay, M., and Bernard, O.A. (2012). Spliceosome and other novel mutations in chronic lymphocytic leukemia and myeloid malignancies. Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, UK 26, 2027-2031.
11. Gaidano, G., Foa, R., and Dalla-Favera, R. (2012). Molecular pathogenesis of chronic lymphocytic leukemia. The Journal of clinical investigation 122, 3432-3438.
12. Garcia-Munoz, R., Galiacho, V.R., and Llorente, L. (2012). Immunological aspects in chronic lymphocytic leukemia (CLL) development. Annals of hematology 91, 981-996.
13. Gladstone, D.E., and Fuchs, E. (2012). Hematopoietic stem cell transplantation for chronic lymphocytic leukemia. Current opinion in oncology 24, 176-181.
Maru, Y. (2012). Molecular biology of chronic myeloid leukemia. Cancer science 103, 1601-1610.
14. Parikh, S.A., and Tefferi, A. (2012). Chronic myelomonocytic leukemia: 2012 update on diagnosis, risk stratification, and management. American journal of hematology 87, 610-619.
Course responsible Julian Walfridsson
Institutionen för medicin, Huddinge


julian.walfridsson@ki.se
Contact person