Syllabus database for doctoral courses

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SYLLABI FOR DOCTORAL COURSES

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Swedish title Psykoneuroimmunologi
English title Psychoneuroimmunology
Course number 2571
Credits 3.0
Responsible KI department Institutionen för klinisk neurovetenskap
Specific entry requirements
Grading Passed /Not passed
Established by Styrelsen för forskarutbildning
Established 2011-10-10
Purpose of the course
Intended learning outcomes At the end of the course the doctoral student will be able to:

Describe the essential concepts in psychoneuroimmunology - the basic mechanisms by which the nervous, the endocrine and the immune system communicate, and why behavior is relevant in this communication.

Critically comment on the literature in the field of psychoneuroimmunology

Choose an adequate design for his/her own research questions in psychoneuroimmunology
Contents of the course The main content of the course is an overview of present knowledge in psychoneuroimmunology: the functional relations between the nervous system, the endocrine system, the immune system and behavior.
Teaching and learning activities Lectures will provide an overview of the essential concepts and the research in the different areas of psychoneuroimmunology for the use of the doctoral student in the preparation of the examination assignment. The doctoral student has access to supervision in the preparation of the written examination.
Compulsory elements Examination seminar. In case of absence from the scheduled examination seminar, another occasion for examination can be arranged as agreed upon with the course leader.
Examination The examinations will be done in a mandatory seminar, with oral as well as written contributions from each participant. The examination has two main parts:

1) Written presentation with a review of a selected topic of psychoneuroimmunology, as agreed upon with the course leader.

2) Written (2-3 pages) and oral presentation of a study that is well motivated in background of the current state of knowledge/lack of knowledge in psychoneuroimmunology.
Literature and other teaching material Lekander, M., Ecological immunology: The role of the immune system in psychology and neuroscience. European Psychologist, 2002. 7(2): p. 98-115.
Tracey, K.J., The inflammatory reflex. Nature, 2002. 420(6917): p. 853-9.
Craig, AD. How do you feel--now? The anterior insula and human awareness. Nat Rev Neurosci, 2009. 10(1): p. 59-70.
Pedersen, B.K. and L. Hoffman-Goetz, Exercise and the immune system: regulation, integration, and adaptation. Physiol Rev, 2000. 80(3): p. 1055-81.
Jonsdottir, I.H., Special feature for the Olympics: effects of exercise on the immune system: neuropeptides and their interaction with exercise and immune function. Immunol Cell Biol, 2000. 78(5): p. 562-70.
Dhabhar, F.S. and K. Viswanathan, Short-term stress experienced at time of immunization induces a long-lasting increase in immunologic memory. Am J Physiol Regul Integr Comp Physiol, 2005. 289(3): p. R738-44.
Segerstrom, S.C. and G.E. Miller, Psychological stress and the human immune system: a meta-analytic study of 30 years of inquiry. Psychol Bull, 2004. 130(4): p. 601-30.
Elks, C.M., Francis J., Central adiposity, systemic inflammation, and the metabolic syndrome. Curr Hypertens Rep. 2010 Apr;12(2): p. 99-104.
Engelhardt, B. and R.M. Ransohoff, The ins and outs of T-lymphocyte trafficking to the CNS: anatomical sites and molecular mechanisms. Trends Immunol, 2005. 26(9): p. 485-95.
Aloisi, F., Immune function of microglia. Glia, 2001. 36(2): p. 165-79.
Harbuz, M.S., A.J. Chover-Gonzalez, and D.S. Jessop, Hypothalamo-pituitary-adrenal axis and chronic immune activation. Ann N Y Acad Sci, 2003. 992: p. 99-106.
Nocker, W.A. and H. Renz, Neurotrophins and asthma: Novel insight into neuroimmune interaction. Journal of Allergy and Clinical Immunology, 2006(117): p. 67-71.
Dantzer, R., O'Connor, J.C., Freund, G.G., Johnson, R.W. and K.W. Kelley, From inflammation to sickness and depression: when the immune system subjugates the brain. Nat Rev Neurosci, 2008 .9(1): p. 46-56.
Wilson, C.J., C.E. Finch, and H.J. Cohen, Cytokines and cognition--the case for a head-to-toe inflammatory paradigm. J Am Geriatr Soc, 2002. 50(12): p. 2041-56.
Zachariae, R., Hypnosis and immunity, in Psychoneuroimmunology, third edition, R. Ader, D.L. Felten, and N. Cohen, Editors. 2001, Academic Press: New York. p. 133-160.
Raap, U. and A. Kapp, Neuroimmunological findings in allergic skin diseases. Curr Opin Allergy Clin Immunol, 2005. 5(5): p. 419-24.
Grippo, A.J. and A.K. Johnson, Biological mechanisms in the relationship between depression and heart disease. Neurosci Biobehav Rev, 2002. 26(8): p. 941-62.
Bryant, P.A., J. Trinder, and N. Curtis, Sick and tired: Does sleep have a vital role in the immune system? Nat Rev Immunol, 2004. 4(6): p. 457-67.
Ader, R., Conditioned immunomodulation: research needs and directions. Brain Behav Immun, 2003. 17 Suppl 1: p. S51-7.
Course responsible Anna Nixon Andreasson
Institutionen för klinisk neurovetenskap

0737078903
Anna.Andreasson@ki.se

Contact person Mats Lekander
Institutionen för klinisk neurovetenskap


Mats.Lekander@ki.se