Course catalogue doctoral education - VT24

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Title Tuberculosis infection and disease
Course number 2443
Programme X- Används inte längre - Global hälsa (WHP)
Language English
Credits 1.5
Date 2011-02-21 -- 2011-02-25
Responsible KI department Institutionen för medicin, Huddinge
Specific entry requirements
Intended learning outcomes At the end of the course, students should have a broad knowledge in TB, covering several competence areas and be able to descibe and discuss:
- clinical symptoms and immunopathogenesis both in TB infection and in relation to additional co-infections
- the global burden of TB and the differences between low and high income countries
- TB control programmes and challenges including TB diagnosis, treatment, drug-resistance and vaccine strategies
- the molecular mechanisms and immunological host-pathogen interactions that occur in TB infection and disease, both at the cellular and systemic level
Contents of the course Basic as well as deepened knowledge about the infectious disease tuberculosis (TB) will be provided. The course will cover several arms of TB infection and disease, with a focus on clinical and research aspects of TB. International public health aspects on TB will be combined with an overview on epidemiology, bacteriology, clinical disease, immunology, pathogenesis, diagnostic methods and principles of vaccines and therapy. Methods for prevention and control of infection and disease especially in low and middle income countries will be evaluated. The concept of multidrug- (MDR-TB) and extensively drug-resistant (XDR-TB) will be outlined, including molecular mechanisms of drug resistance. The interaction between TB and co-infections such as HIV will also be reviewed. Typically, the course schedule will involve a daily theme as follows: Day 1.) Clinical TB and global health, Day 2.) TB immunology and implications in diagnosis, Day 3.) Drug-resistance and molecular testing of TB, Day 4.) TB treatment and vaccines, Day 5.) Study questions and group assignment. Note that the schedule may change slightly from one year to another.
Teaching and learning activities The course will consist of a mixture of lectures, study questions and group assignments. Invited speakers, mostly from different universities and institutes in Sweden, will give lectures in their specific competence area. Lectures will provide study questions that should be discussed in written and oral form by the students. Group work could focus on TB or another bacterial infection than TB. For the group assignment, the students will have access to computer rooms in the KI library, in order to gain necessary information and to prepare the oral and written part of their group work.
Compulsory elements It is compulsory to attend all sessions including study questions and group assignment in order to pass the course. Absence has to be compensated by an individual written assignment provided by the course leader.
Examination The last day of the course will summarize study questions and group assignment. Group discussions will be combined with written coursework and oral presentations of group assignments.
Literature and other teaching material Necessary literature including articles, book chapters or else will either be provided by the course leader or be found on the internet.
Number of students 20 - 25
Selection of students 1.) Time since doctoral registration, 2.) motivational text.
More information The course will take place at Karolinska University Hospital Huddinge, Monday to Friday, 09.00-18.00. Normally lectures in the morning and after lunch. Literature studies in the afternoon. Basic as well as deepened knowledge about the infectious disease tuberculosis (TB) will be provided. The course will cover several arms of TB infection and disease, with a focus on clinical and research aspects of TB. International public health aspects on TB will be combined with an overview on epidemiology, bacteriology, clinical disease, immunology, pathogenesis, diagnostic methods and principles of vaccines and therapy. Methods for prevention and control of infection and disease especially in low and middle income countries will be evaluated. The concept of multidrug- (MDR-TB) and extensively drug-resistant (XDR-TB) will be outlined, including molecular mechanisms of drug resistance. The interaction between TB and co-infections such as HIV will also be reviewed. Typically, the course schedule will involve a daily theme as follows: Day 1.) Clinical TB and global health, Day 2.) TB immunology and implications in diagnosis, Day 3.) Drug-resistance and molecular testing of TB, Day 4.) TB treatment and vaccines, Day 5.) Study questions and group assignment. Note that the schedule may change slightly from one year to another.
Additional course leader
Latest course evaluation Not available
Course responsible Susanna Brighenti
Institutionen för medicin, Huddinge

Susanna.Brighenti@ki.se
Contact person -