Course catalogue doctoral education - VT20

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Title Function B - to Design Procedures and Projects Involving Research Animals
Course number 3214
Programme 0-Inte del av forskarutbildningsprogram
Language English
Credits 3.0
Date 2020-03-03 -- 2020-04-02
Responsible KI department Komparativ medicin
Specific entry requirements Previous education in laboratory animal science to carry out scientific procedures on animals (i.e. Function A).
Purpose of the course The course provides education to doctoral students who will be involved in the design of scientific procedures involving research animals as part of their research. This course also provides education in laboratory animal science to doctoral students who are not necessarily involved with studies using animals but will need to be able to analyze scientific literature and/or data that have been generated from animal studies.
Intended learning outcomes After completion of this course, students should be able to meet the defined learning outcomes as set out in the EU Education and Training guidelines, specifically for modules 7, 9, 10-11. The list of suggested learning outcomes by the EU guidelines is comprehensive, but in summary, participants will acquire the knowledge to design and evaluate procedures involving research animals. At the end of the course participants should be able to:

• Describe appropriate methods of handling and restrain, and appropriate techniques needed to carry out or plan minimally invasive procedures without anesthesia. [EU 7]
• Demonstrate a broader and deeper level of understanding of legal requirements and responsibilities, ethics, animal welfare, and the 3Rs in relation to animal research. [EU 9]
• Recognize principles of good experimental design of animal studies. [EU 10]
• Relate principles of good scientific practice in research using animals. [EU 11]
Contents of the course This course follows the latest EU guidelines for the education and training of persons designing procedures and projects using animals, i.e. Function B, as stated in the EU Directive 2010/63 and the Swedish legislation (SJVFS 2017:40) on the protection of animals used for scientific purposes. In particular, this course will cover the Function B-specific modules established in the European Union guidelines such as modules EU 7 (Minimally invasive procedures without anesthesia for rodents and lagomorphs), EU 9 (Ethics, animal welfare, and the 3Rs - level 2), EU 10 (Design of procedures and projects - level 1), and EU 11 (Design of procedures and projects - level 2).



The course contents are based on the EU Education and Training Framework and include:
• Procedures on animals.
• Regulations affecting animal research.
• Ethics, animal welfare and the 3Rs.
• Experimental design and statistical analysis of animal studies.
• Good scientific practice in animal research.

Teaching and learning activities Face-to-face seminar lectures, e-learning, individual work (home study), group work, student’s presentations, in-class discussions and interactions.
Compulsory elements All parts of the course and active participation is compulsory. Missed parts must be compensated. In order to participate in the final exam, at least 70% of the lectures must have been attended. Missed parts must be compensated for in agreement with the course leader.
Examination A final exam containing short answer questions and/or multiple choice questions will be used to assess theoretical knowledge. Feedback will also be given to student’s presentations.
Literature and other teaching material Handouts and e-learning material will be made available online at the learning platform Ping Pong or Canvas. As the key reference material, the students are referred to:

1. EU legislation on the Protection of Animals Used in Science (2010). Directive 2010/63/EU.
2. Swedish legislation on the Protection of Animals Used in Science (2018). L150, SJVFS 2017:40.
3. European Commission (2014). National competent authorities for the implementation of Directive 2010/63/EU on the protection of animals used for scientific purposes. A working document on the development of a common education and training framework to fulfil the requirements under the Directive. Brussels, 19-20 February 2014.
4. Handbook of Laboratory Animal Science: Essential Principles and Practices. Hau, Jann; Schapiro, Steven Jay 3. ed.: Boca Raton: CRC Press, cop. 2011 - 723 s. ISBN:978-1-4200-8455-9 (vol.1) LIBRIS-ID:12096142
5. Lab Animal Welfare. https://flairelearning.com/course/recognition-and-prevention-of-pain-suffering-and-distress
6. Lab Animal Anaesthesia. https://flairelearning.com/course/anaesthesia-for-minor-procedures/
7. Lab Animal Euthanasia. https://flairelearning.com/course/humane-methods-of-killing-laboratory-animals/
8. Experimental design and statistics of animal studies. http://www.3rs-reduction.co.uk/
Number of students 5 - 10
Selection of students This course is primarily intended for principal investigators, but selected doctoral students at the last stage of their studies will be accepted. Thus, preference will be given to doctoral students working with animal models in the last stage of their projects. If necessary, a selection criterium will be used based on the date for registration as a doctoral student (priority given to earlier registration date) and on the relevance of the course syllabus for the applicant's doctoral project.
More information Face-to-face lectures will be held in 8 separate days between approx. 9 am and 5 pm. This course is FELASA-accredited and follows the specific learning outcomes for Function B modules in accordance with the EC Education and Training Framework, recently endorsed by the new Swedish L150 (SJVFS 2017:40).
Additional course leader
Latest course evaluation Course evaluation report
Course responsible Rafael Frias
Komparativ medicin
085246660
rafael.frias@ki.se
Contact person -