Course catalogue doctoral education - VT20

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Title Immunogenicity: Immune responses against biological drugs
Course number 3067
Programme Allergi, immunologi och inflammation (Aii)
Language English
Credits 1.5
Date 2020-03-30 -- 2020-04-03
Responsible KI department Institutionen för klinisk neurovetenskap
Specific entry requirements
Purpose of the course Understanding of central terms and definitions in the field of immunogenicity, used in research and in clinical applications. To become familiar with the identified molecular and cellular immunological processes that trigger and increase the risk for developing anti-drug antibodies (ADA). Understanding of how immunogenicity needs to be taken into consideration all the way from choosing your biological target of treatment, to drug development, approval, clinical routine and individualized therapy and health care practice.
Intended learning outcomes At the end of the course the student should be able to:
- Understand what determines the immunogenicity of drugs and why they differ in this respect.
- Give examples of different methods of how to measure drug level and ADA.
- Understand the algorithms needed in clinical practice and what consequences ADA might have for treatment decision, safety and efficacy.
- Integrate this knowledge in your own research project or a disease and treatment of choice.
Contents of the course The course will give you an orientation of the clinical research fields where treatment with biopharmaceuticals are important and how the immune system can react against different biopharmaceuticals. It will include the diseases MS, RA, IBD, and SLE and biopharmaceuticals like IFNbeta, natalizumab, rituximab, TNF-blockers as well as the biosimilars for these. A range of immunoassay methodologies that can be used to measure drug levels and ADA will be presented and the clinical relevance of the test results discussed. The course will also give insights on the type of research being done to identify risk factors for ADA, and optimisation of drug design, production and administration to minimize the risk. Ways to improve treatment regiments adopted to results of drug level and ADA, as well how to monitor and store data in clinical routine will be discussed.
Teaching and learning activities Lectures, individual essays, peer-review and oral presentation.
Compulsory elements Lectures, essay, peer-review and oral presentation. Absence from lectures can be compensated for by writing an additional essay on the subject missed.
Examination Essay, peer-review and oral presentation.
Literature and other teaching material Articles selected by the teachers and by own literature search in PubMed or other data bases.
Number of students 10 - 30
Selection of students Selection will be made according to the applicant’s written motivation to take the course.
More information
Additional course leader Nastaya Kharlamova, Per Martis, Nicky Dunn
Latest course evaluation Course evaluation report
Course responsible Anna Fogdell-Hahn
Institutionen för klinisk neurovetenskap

Anna.Fogdell-Hahn@ki.se

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