Course catalogue doctoral education - VT20

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Title Cytostatic Drugs in Research and Cancer Treatment
Course number 3108
Programme Tumörbiologi och onkologi (FoTO)
Language English
Credits 1.5
Date 2020-05-04 -- 2020-05-08
Responsible KI department Institutionen för laboratoriemedicin
Specific entry requirements
Purpose of the course The present course aims to provide the participants with a comprehensive overview about cytostatic drugs and their role in modern cancer therapy. By the end of the course, the student will know how to handle cytostatic drugs in laboratory experiments, have an overview of their use in cancer treatment, their mechanism of action and their role in research. Moreover, the student will have an awareness of recent advances in cancer treatment, including drug development, target therapy and drug administration.
Intended learning outcomes After passing the course, students
- will be able explore the mechanism of action of the cytostatic and targeted drugs in order to understand cell death and drug resistance in cancer therapy.
- will understand the mechanisms underlying the interaction between cytostatic drugs and other drugs in order to minimize the adverse effects.
- will have an overview over new strategies for cancer treatment including the use of nanocarriers and nanoparticles.
- will understand the mechanisms underlying pain caused by cytostatic and targeted drugs including chemotherapy induced peripheral neuropathy (CIPN).
- will understand the effect of anticancer drugs on the immune system.
- will understand safety regulations and routines according to Swedish legislation and will be able to implement these in their daily work.
Contents of the course Cytostatic and targeted anticancer drugs
Mechanism of action of cytostatic and targeted anticancer drugs
Modern therapies include the use of antibodies, cellular therapy and nanocarriers in cancer treatment.
Drug-drug interaction between cytostatic drugs and other simultaneously used drugs.
Basic aspects of pharmacokinetics, pharmacodynamics and pharmacogenetics of cytostatic and targeted anticancer drugs
Mechanisms underlying pain induced by cancer terapy.
Treatment strategies using combination of cytostatic and targeted anticancer drugs
Mechanisms underlying cell-death induced by cytostatic and targeted drugs.
Drug resistance in cancer therapy
The effect of anticancer drugs on the immune system
The Swedish legislation and safety regulations ¿how to work and handle the cytotoxic drugs AFS 2005:5¿
Teaching and learning activities The course consists of lectures, seminars and group work.
Compulsory elements The seminar on safety regulations, group work and the examination seminar are compulsory. In case of absence, the student has to acquire appropriate knowledge from the recommended literature, may get a consultation with the course leader (if needed) and write short report.
Examination The course assignment will consist on a formative assessment based on individual presentation (10-15 minutes) as well as a written assignment (3-4 A4 pages) on the combination of cytostatic and targeted drugs in clinical use. The presentation should include the following issues: mechanisms of action, rational behind the treatment, side effects, efficacy, and interactions.
Literature and other teaching material The students will be provided in advance with relevant literature (review articles, original publications, references to book chapters).
Number of students 10 - 25
Selection of students Selection will be based on 1) the relevance of the course syllabus for the applicant's doctoral project (according to written motivation), 2) start date of doctoral studies (priority given to earlier start date)
More information The course will be held in Novum, Flemingsberg, level 4, conference room Cellen. The information regarding exact time will be sent to course participants along with the course schedule.
This course has previously been given with number 1741.
Additional course leader Ying Zhao, ying.zhao.1@ki.se
Latest course evaluation Course evaluation report
Course responsible Moustapha Hassan
Institutionen för laboratoriemedicin
08-585 838 62
Moustapha.Hassan@ki.se
Contact person Ying Zhao
Institutionen för laboratoriemedicin

ying.zhao.1@ki.se

ECM/KFC; Novum, Lab 601; Hälsovägen 7