Course catalogue doctoral education - VT20

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Title Translational Paediatric Oncology in the Era of Immunotherapy and Omics
Course number 3022
Programme Tumörbiologi och onkologi (FoTO)
Language English
Credits 1.5
Date 2020-03-30 -- 2020-04-03
Responsible KI department Institutionen för kvinnors och barns hälsa
Specific entry requirements
Purpose of the course - To enable to obtain a comprehensive overview of the different domains within childhood cancer research and to understand the historical milestones forming the paradigms that have led to a cure of 8 out of 10 children with cancer
- To give an insight into the current limitations and problems of childhood cancer treatment
- To enable to get an understanding of how new methodologies in molecular biology increase our knowledge about tumourigenesis and tumour evolution.
- To provide an opportunity to hypothesise and develop ideas about how to cure the remaining 2 out of 10 children with cancer.
Intended learning outcomes At the end of the course the students should be able to:

- Summarise the basic epidemiological data, tumour biology and genetics, novel therapy modalities like targeted therapies and immunotherapy, including side effects, late effects and follow up within the field of paediatric oncology.
- Discuss the ethical issues around childhood cancer research.
- Describe and understand the principles of treatment, existing therapies, new targeted therapies and personalized medicine.
- Explain and theorize about the link between cancer cell biology, tumour microenvironment, immunology, genetics, and drug treatments - current and development of new drugs.
- Understand and discuss the current experimental methodology applied to paediatric oncology research such as in vivo, in vitro and in silico models.
- Critical comment on research findings regarding paediatric oncology research.
Contents of the course Introduction to research on paediatric oncology for PhD students and junior postdocs, with research projects in this specific area or in an adjacent area. The students will be presented with and will discuss problems, possibilities, and research models that are specific for the research area of paediatric oncology. The course will provide a general introduction to the field and focus on distinct, but interconnected topics specific for paediatric oncology, namely ethics, epidemiology, tumour biology and genetics, existing and novel targeted drug treatments as well as immunotherapy, and side effects, late effects and follow up. The last day will be dedicated to a symposium with invited lecturers that are renowned expert in their fields.
Teaching and learning activities Lectures, seminars, group exercises with supervised discussions. To promote active discussion and participation, each student will prepare a short oral presentation on their current or intended research before the course and submit a short written abstract on this no later than two weeks before the course start. The course will include a one-day mini research symposium.
Compulsory elements All course activities are compulsory. Absence can be compensated for by other activities in agreement with the course leaders.
Examination To pass the course the students must show that they have reached the learning outcomes of the course. Each students should prepare a scientific poster on an actual or hypothetical childhood cancer research project, including one of the following topics: epidemiology, register research, tumour biology and genetics, novel therapy modalities like targeted therapies and immunotherapy, and give an oral presentation of the poster and answer to critical questions of the audience consisting of the course leaders and course participants. Each participant in the course needs to be able not only to answer questions in a satisfactory way but also to raise relevant questions and to be able to discuss in line with the intended learning outcomes of the course.
Literature and other teaching material Current review articles, at least two on each topic (sent to the students in advance), in addition distributed material, including articles and book chapters.
Number of students 16 - 28
Selection of students Selection will be based on 1) the relevance of the course syllabus for the applicant's doctoral project (according to written motivation), 2) start date of doctoral studies (priority given to earlier start date)
More information The course starts Monday. During Tuesday, Wednesday and Thursday full days are scheduled with lectures and seminars. The course concludes with a research symposium on Friday with several known experts in the field. The course will be located at KI Solna.
Additional course leader Additional course leaders are Desiree Gavhed, Shanie S. Hedengren, Frida Holm and Nikolas Herold.
Latest course evaluation Course evaluation report
Course responsible Malin Wickström
Institutionen för kvinnors och barns hälsa
08-51772989
Malin.Wickstrom@ki.se
Contact person Nikolas Herold
Institutionen för kvinnors och barns hälsa

nikolas.herold@ki.se


Désirée Gavhed
Institutionen för kvinnors och barns hälsa

Desiree.Gavhed@ki.se


Frida Holm
Institutionen för kvinnors och barns hälsa

frida.holm@ki.se


Shanie Saghafian-Hedengren
Institutionen för kvinnors och barns hälsa

shanie.hedengren@ki.se