Course catalogue doctoral education - HT19

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Title Cell Death and Cancer
Course number 3202
Programme Tumörbiologi och onkologi (FoTO)
Language English
Credits 1.5
Date 2019-11-25 -- 2019-11-29
Responsible KI department Institutet för miljömedicin
Specific entry requirements
Purpose of the course The purpose of this course is to bring PhD students and young researchers to an advanced level in the fast-developing scientific fields of cell death and cancer, and to provide knowledge that can be applied both for basic, pre-clinical and clinical research. The participants will have the possibility to develop their analytical and critical thinking and to obtain a broad knowledge and a systematic understanding of the role of disturbances of various cell death mechanisms in tumor development as well as how to use this knowledge in order to target cancer cells and increase their sensitivity to therapy.
Intended learning outcomes After the course the students will be able to show a detailed knowledge concerning the relationship between cell death and proliferation as well as a role of cell death in tumour progression, metastasis and cancer therapy. Students will be able to analytical and critical thinking.
Contents of the course The course will start with an introduction to the field of cell death (apoptosis) and its role in biology and medicine. Then the lecturers will organize their presentations to give a comprehensive and pedagogical overview of the research area and discuss the latest results available on: (i) explanation of cancer as a complex genetic disease; (ii) general mechanisms of cell death; (iii) Autophagic cell death; (iv) regulators of cell death and survival; (v) mitochondrial functioning in cancer cells; (vi) Role of c-myc in carcinogenesis and cell death; (vii) efficiency of cell death machinery in tumour cells; (viii) Role of growth factors in carcinogenesis and apoptosis; (ix) tumour promoters and suppressors in regulation of cell death; (x) Tumor viruses and apoptosis; (xi) Epigenetic deregulation in cancer; (xii) Role of immune response in carcinogenesis and apoptosis; (xiii) Senescence, apoptosis and therapy; (xiv) Role of cell-matrix interactions for cell survival; (xv) Role of neovascularization in regulation of cell death; (xvi) DNA damage recognition, signalling and repair: links with the cell cycle progression, cell death and carcinogenesis; (xvii) Kinases, apoptosis and cancer drugs; (xviii) miR's in cancer and cell death. the course will be ended with a general discussion on the hot topics in cell death and cancer.
Teaching and learning activities The course will consist of lectures and seminars and literature studies. At the end of each seminar there will be a discussion. In addition, students will present and discuss their PhD projects including the methodology.
Compulsory elements Lectures, seminars and presentation of projects are compulsory. Missed lectures and seminars have to be compensated for by other activities after discussion with the course leader.
Examination The course assessment will be based on individual oral presentation on a selected topic of the course. The course organiser will be in charge of the examination and will provide immediate feedback in line with the concept of formative assessment. The presentation will be designed in a way to help the course organizer (examiner) to be sure that the learning outcomes are reached by the students.
Literature and other teaching material Students will be provided with a compendium containing approximately 15 essential articles.
Number of students 10 - 30
Selection of students Selection will be based on 1) the relevance of the course syllabus for the applicant's doctoral project (according to written motivation), 2) date for registration as a doctoral student (priority given to earlier registration date)
More information The course will take place from Monday to Friday (from 9.00 up to 17.00). The course will be held at the Institute of Environmental Medicine (Nobels väg 13).
The course has previously been given with number 2267.
Additional course leader
Earlier evaluation of the course Evaluation report
Course responsible Boris Zhivotovsky
Institutet för miljömedicin
0852487588
Boris.Zhivotovsky@ki.se

Nobels väg. 13

17177
Stockholm
Contact person -