Course catalogue doctoral education - HT19

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Title Human Papilloma Virus - from molecular biology to global health - an eLearning course
Course number 3030
Programme Biology of infection and global health (BIGH)
Language English
Credits 1.5
Date 2019-09-09 -- 2019-10-18
Responsible KI department Department of Laboratory Medicine
Specific entry requirements The pre-course knowledge prerequisites are BSc or equivalent in biomedicine.
Purpose of the course The course aims to provide knowledge of the scientific background of the biology of Human Papilloma Virus (HPV) infection, the burden of HPV associated diseases, screening and vaccination. In this one-week course on the global health importance of Human Papilloma Virus (HPV) infection, you will learn about HPV molecular biology and mechanisms of virus-induced cancer, screening of cervical samples, using HPV testing as well as bioinformatic analysis and methods for quality assurance and follow-up of programs of HPV-based screening and vaccination. You will explore how this knowledge can be applied to reduce the risk of disease. Taking part in an online discussion thread will give you a chance to reflect on the impact of HPV vaccination and screening in society. You will also learn about HPV analysis methods.
Intended learning outcomes On completion of the course the student should be able to: 
1 Understand and describe HPV infection and the burden of HPV-associated diseases. 
2 Understand and describe methods for detection of HPV and the bioinformatics methods for HPV classification. 
3 Describe the best practice for organized cervical screening. 
4 Assess internationally standardized quality indicators of cervical screening 
5 Interpret and validate results from screening and vaccination and their implications on the cancer burden. 
Contents of the course Block 1, Day 1-3: Molecular Biology of HPV  Block 2, Day 3-4: Cervical Screening and HPV vaccination  Block 3, Day 5-6: Quality Assurance and Follow-up of HPV-targeted Cancer Control 
Teaching and learning activities The course is internet-based and is open for 5 weeks in total. Each day in the first week video lectures, assignments relating to the contents of the video lectures and supplementary material in the form of open access scientific articles will be released. In some cases, the assignments will be in the form of lecture quizzes and in some cases you will be asked to post in a discussion forum. 
Compulsory elements Participation in lecture quizzes, discussion thread, and examination is mandatory. The discussion thread will be organized and supervised according to the established format of the open source eLearning software Moodle. The teachers supervising the discussion thread will ensure that the participants reach the pre-defined educational goals.  
Examination You will need to have completed the learning activities before being able to participate in the final examination. Examination will be scheduled on two occasions, one immediately after the first two weeks and the other after five weeks. Using a webcam, you will identify yourself by taking a photo of yourself together with your government-issued photo ID. Examination will be internet-based in the form of multiple choice questions and writing assignments.  
Literature and other teaching material IARC HPV Monograph 100B-11: http://monographs.iarc.fr/ENG/Monographs/vol100B/mono100B-11.pdf  WHO HPV Laboratory Manual  http://www.who.int/immunization/hpv/learn/ hpv_laboratory_manual__who_ivb_2009_2010.pdf 
Number of students 8 - 50
Selection of students Selection will be based on 1) the relevance of the course syllabus for the applicant's doctoral project (according to written motivation), 2) date for registration as a doctoral student (priority given to earlier registration date)
More information Note that this is an online course where teaching and learning activity will be focused during the first two weeks of the period, ending with a formal exam. A new exam opportunity will be arranged at the end of week 5 of the period.
Additional course leader Teachers are: Karin Sundström, MD, PhD, research coordinator, Dept of Laboratory medicine, Karolinska Institutet Emilie Hultin, PhD, research coordinator, Dept of Laboratory medicine, Karolinska Institutet Helena Faust, PhD, research coordinator, Dept of Laboratory medicine, Karolinska Institutet Miriam Elfström, PhD, MPH, research associate, Dept of Laboratory medicine Karolinska Institutet, process leader Regional Cancer Centre Stockholm-Gotland Sara Arroyo Muhr, PhD, Bioinformatician, Dept of Laboratory medicine, Karolinska Institutet Carina Eklund, research coordinator, Dept of Laboratory Medicine, Karolinska Institutet Joakim Dillner, MD, Professor of Infectious Disease Epidemiology, Dept of Laboratory medicine, Karolinska Institutet, Director of R&D Karolinska University Laboratory
Earlier evaluation of the course Evaluation report
Course responsible Karin Sundström
Department of Laboratory Medicine

karin.sundstrom@ki.se
Contact person Karin Sundström
Institutionen för laboratoriemedicin

karin.sundstrom@ki.se