Course catalogue doctoral education - HT19

  • Ansökan kan ske mellan 2019-04-15 och 2019-05-15
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Title Translational Molecular Imaging in Neurodegenerative Disorders
Course number 3186
Programme Neurovetenskap
Language English
Credits 3.0
Date 2019-10-14 -- 2019-10-25
Responsible KI department Institutionen för neurobiologi, vårdvetenskap och samhälle
Specific entry requirements nej
Purpose of the course The aim of this course is to give a state of the art overview of diverse molecular imaging techniques and their in vitro, clinical and paraclinical applications in neurodegenerative disorders with a focus on dementia. This course also provides hands-on experience through different workshops in diverse multifaceted techniques that are useful in different research fields.
Intended learning outcomes After the course the students will understand the main pathophysiological features of neurodegenerative diseases, with a focus on dementia disorders.
After the course a doctoral student shall be able to:
- Account for recent advances in CSF and in vivo brain imaging biomarkers
- Account for the theoretical basis of main techniques used in molecular imaging and biochemical analyses used on living subjects and biological materials
- Perform key in vitro and in vivo techniques used in screening and identifying new PET tracers
- Develop, evaluate and validate in vivo brain and CSF markers
- Collect, process, analyze and interpret data of key techniques
- Apply what they have learned to their own research work
Contents of the course This course will focus on scientific approaches used to study neurodegenerative disorders. Topics for the practical experiments will include the following: demonstrations of molecular imaging techniques that are used to study function and pathological changes in the brain of living patients/animal models including PET/micro-PET, demonstrations of MRI techniques for structural brain analysis, histopathological examination of brain lesions in human post-mortem brain tissue and autoradiography, radio-ligand binding and enzyme kinetic techniques to study localization of receptors, binding potential and affinity of ligands, changes in neurotransmitter function and to correlate these with other pathological changes in the brain, quantitative assays of biomarkers and proteins involved in signaling pathways in biological fluids and in the brain using brain homogenate, human CSF and/or plasma etc. The course will also discuss, provide a deep understanding, some hands-on training on how to setup and use common in-house sensitive assays, their advantages, applicability and caveats.
Teaching and learning activities The course is full time (10 days) and will be organised as an integration of lectures, combined with practical laborations, demonstrations and literature studies.
Compulsory elements All parts of the course are mandatory. Absence from any of these will be compensated for by extra individual assignments provided by the course organizers
Examination All the intended learning outcomes will be assessed by a combination of written examination, written reports for the practical workshops, and oral presentation.
Literature and other teaching material Students will receive specific literature to prepare for practical experiments and for the final examination. The literature will be selected journal articles and lab handouts.
Number of students 10 - 15
Selection of students Selection will be based on 1) the relevance of the course syllabus for the applicant's doctoral project (according to written motivation), 2) date for registration as a doctoral student (priority given to earlier registration date)
More information The course will be held at the KI Flemingsberg Campus at the NEO building. This course has previously been given with number 2315.
Additional course leader
Earlier evaluation of the course Evaluation report
Course responsible Taher Darreh-Shori
Institutionen för neurobiologi, vårdvetenskap och samhälle
Contact person Elena Rodriguez-Vieitez
Institutionen för neurobiologi, vårdvetenskap och samhälle

Daniel ferreira padilla
Institutionen för neurobiologi, vårdvetenskap och samhälle

Laetitia Lemoine
Institutionen för neurobiologi, vårdvetenskap och samhälle