Course catalogue doctoral education - HT19

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Title Survey of Molecular Endocrinology
Course number 3174
Programme Metabolism och endokrinologi
Language English
Credits 3.0
Date 2019-10-07 -- 2019-10-18
Responsible KI department Institutionen för laboratoriemedicin
Specific entry requirements
Purpose of the course The purpose of the course is to provide doctoral students an in-depth understanding of the cell and molecular mechanisms as well as the fundamental principles of hormone action in tissues in health and disease. To prepare for public speaking infront of a scientific audience students are required to display their knowledge through a formal presentation on a current research topic in cellular and molecular endocrinology. An additional emphasis will be placed on how state-of-the art methodologies have been utilised to further our knowledge of endocrine signalling.
Intended learning outcomes After successfully completing this course, students should have obtained a fundamental knowledge of molecular endocrinology and acquired the following abilities:
1. to explain the molecular mechanisms by which peptide and steroid hormones activate their receptors to provoke their biological effects
2. to comprehend how the actions of hormones are involved in both health and disease
3. to construct pathways of the endocrine systems that link control and production of hormones in specific tissues with the actions of these hormones in their respective target organs
4. to develop an in-depth comprehensive knowledge of endocrinology from a physiological, cellular, and molecular perspective
Contents of the course -This course will cover current topics involved in hormone signalling at a cellular and molecular level from receptor interaction to gene response including receptor structure and function interactions with their hormone, second messengers, transcriptional regulation and autocrine and paracrine feedback signalling pathways. -The course will emphasise the critical understanding of how hormones act at the molecular level and why their signalling pathways synergise or antagonise each other under normal and pathological physiological conditions. -A survey of current topics in endocrinology will be used to exemplify the concepts of the course such as stem cell commitment and differentiation, the molecular signalling and genetics of embryogenesis; reproductive determination and differentiation; cancer stem cell dedifferentiation and carcinogenesis; hormonal regulation of gene expression, steroid and peptide hormone action via paracrine, autocrine signalling; endocrine mechanisms of receptor interaction, transmembrane and intracellular signal transduction, ionic signalling, and regulation of nuclear gene transcription. -To develop our in-depth comprehensive knowledge of endocrinology from a physiological, cellular, and molecular perspective the course will cover current methodologies applied in research.
Teaching and learning activities The course will consist of cathedral-style lectures to exposure students to fundamental molecular endocrine concepts, current topic seminars to exemplify concepts, and student-led seminars and discussions to allow the students an opportunity to utilize conceptual knowledge within an informal environment.
Compulsory elements The students are expected to attend all lectures and seminars. They are expected to actively participate in discussions. Missed sessions may be replaced by written tasks adapted to the situation.
Examination 1. one written peer evaluation report Each student will be assigned one team led presentation to critique both presenters and journal article. The critique will be formulated in a grant style format. The student will be expected to review the specific topic within molecular endocrinology that the article emphasizes. Then create a testable question and develop a hypothesis based on the topic. Then develop a methodological approach to prove the hypothesis. The student teams that present the article will be considered experts in that topic and the student will critique their position with in the field. (Learning outcomes 1-4). 2. one final exam The final written exam will assess the fundamental principles in learning outcomes 1-4.
Literature and other teaching material Recommended reading Textbooks 1. Molecular Endocrinology, Editor Patricia Joseph-Bravo, 2006, Research Signpost. 2. Molecular Endocrinology 3rd Edition, Editior Franklyn F. Bolander, 2005, Elsevier Academic Press. Only specific chapters will be used from each textbook. Research article: articles will be provided to students prior to course start date.
Number of students 8 - 20
Selection of students Selection will be based on 1) the relevance of the course syllabus for the applicant's doctoral project (according to written motivation), 2) date for registration as a doctoral student (priority given to earlier registration date)
More information The course was previously given with the number 2381, as shown in the course evaluation below.
Additional course leader John Flanagan
Earlier evaluation of the course Evaluation report
Course responsible Amarjit Saini
Institutionen för laboratoriemedicin

amarjit.saini@ki.se
Contact person John Flanagan
Institutionen för laboratoriemedicin
0704816995
john.flanagan@ki.se

CMM, L8:01
Andrology and Molecular Endocrinology Units
171 76
Solna


Amarjit Saini
Institutionen för laboratoriemedicin

amarjit.saini@ki.se