Kurskatalog forskarutbildning - VT19

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Titel Psychoneuroimmunology
Kursnummer 2571
Program 1-Ingår i flera program
Språk Engelska
Antal högskolepoäng 3.0
Datum 2019-03-04 -- 2019-03-15
Kursansvarig institution Institutionen för klinisk neurovetenskap
Särskild behörighet
Kursens syfte Psychoneuroimmunology is the study of the functional and bi-directional relationships between the nervous system, the endocrine system, the immune system and behavior. The main purpose of the course is to provide the student with an overview of present knowledge in this field and to offer an opportunity to apply a cross-disciplinary mechanistic perspective across physiological and pathological conditions. The students are given good opportunities to network and to interact with leading national and international researchers in a quickly developing area. We also wish this course to be an opportunity to interact with other PhD-students with overlapping research interests.
Kursens lärandemål At the end of the course, the doctoral student will be able to:
- Describe the essential concepts in psychoneuroimmunology, the basic mechanisms by which the nervous, the endocrine and the immune system communicate, and why behavior is relevant in this communication.
- Critically comment on the literature in the field of psychoneuroimmunology.
- Choose a suitable design for research in psychoneuroimmunology.
Kursens innehåll - Overview of the essential concepts and the research in the different areas of psychoneuroimmunology. - Description of the adaptive and pathological consequences of immune activation on brain functions and behaviour, including fatigue, pain, mood regulation, social behaviour and neuropsychiatric symptoms. - Description of modulation of the immune system by brain inputs, such as during stress. - Opportunity to understand how behaviours can be pro-actively regulated to improve overall defence against microbes.
Arbetsformer Lectures will provide an overview of the essential concepts and the research in the different areas of psychoneuroimmunology for the use of the doctoral student in the preparation of the examination assignment (written and oral presentations). The doctoral student has access to supervision in the preparation of the written examination. The course will include time to prepare the written and oral presentations of research projects on specific psychoneuroimmunology topics. The oral presentations will take place during a seminar in the end of the course.
Obligatoriska moment Examination seminar, with both oral and written contributions from each participant. In case of absence from the scheduled examination seminar, another occasion for examination can be arranged as agreed upon with the course leader.
Examination The examinations will be done in a mandatory seminar, with oral as well as written contributions from each participant. The examination has two main parts: 1) Written presentation with a review of a selected topic of psychoneuroimmunology, as agreed upon with the course leader. 2) Written (2-3 pages) and oral presentation of a study that is well motivated in background of the current state of knowledge/lack of knowledge in psychoneuroimmunology.
Kurslitteratur och övriga läromedel - Dantzer R, O'Connor JC, Freund GG, Johnson RW, Kelley KW. Nat Rev Neurosci. 2008 Jan;9(1):46-56. From inflammation to sickness and depression: when the immune system subjugates the brain. - Dooley LN, Kuhlman KR, Robles TF, Eisenberger NI, Craske MG, Bower JE. Neurosci Biobehav Rev. 2018 Sep 7. pii: S0149-7634(18)30216-1. doi: 10.1016/j.neubiorev.2018.09.006. The role of inflammation in core features of depression: Insights from paradigms using exogenously-induced inflammation. - Harrison NA.Curr Top Behav Neurosci. 2017;31:221-248. doi: 10.1007/7854_2016_30. Brain Structures Implicated in Inflammation-Associated Depression. - Kirchhof J, Petrakova L, Brinkhoff A, Benson S, Schmidt J, Unteroberdörster M, Wilde B, Kaptchuk TJ, Witzke O, Schedlowski M. Proc Natl Acad Sci U S A. 2018 Apr 17;115(16):4223-4227. doi: 10.1073/pnas.1720548115. Epub 2018 Apr 2. Learned immunosuppressive placebo responses in renal transplant patients. - Dhabhar FS. Immunol Res. 2014 May;58(2-3):193-210. doi: 10.1007/s12026-014-8517-0. Effects of stress on immune function: the good, the bad, and the beautiful. Additional relevant literature will be provided during the course.
Antal studenter 8 - 40
Urval av studenter Selection will be based on 1) the relevance of the course syllabus for the applicant's doctoral project (according to written motivation), 2) date for registration as a doctoral student (priority given to earlier registration date).
Övrig information Lectures will take place every day, from 09:00 to 16:00. Study days for the final examination will be free of lectures (one day the first week, two days the second week). Lunch: 12:00-13:00 (not included in course). Fika in the afternoon around 14:00-14:30 (included). Lectures from international (Professor Manfred Schedlowski, Essen, Germany; Dr Neil Harrison, Brighton, UK; Dr Jan-Pieter Konsman, Bordeaux, France; Dr Bianka Karshikoff, Stanford University, CA, USA) and national (Professor Mats Lekander, Dr Julie Lasselin, Dr Anna Andreasson, Dr John Axelsson) experts in Psychoneuroimmunology will be held.
The course is given jointly by the doctoral programmes Allergy, immunology and inflamation (Aii) and Neuroscience. See: https://ki.se/en/staff/doctoral-programmes.
Ytterligare kursledare
Tidigare omdöme av kursen omdöme
Kursansvarig Julie Lasselin
Institutionen för klinisk neurovetenskap

julie.lasselin@ki.se
Kontaktpersoner Mats Lekander
Institutionen för klinisk neurovetenskap

Mats.Lekander@ki.se