Course catalogue doctoral education - VT19

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Title Pain mechanisms: From molecules to treatment
Course number 3149
Programme Neurovetenskap
Language English
Credits 1.5
Date 2019-06-03 -- 2019-06-07
Responsible KI department Institutionen för fysiologi och farmakologi
Specific entry requirements -
Purpose of the course The purpose of the course is to give doctoral students an insight to pain mechanisms and pain biology, the impact of pain on human health and quality of life as well as to discuss the available treatment options and ongoing research aiming for pain relief. The participants will have the opportunity to learn and discuss the application of cutting edge technologies, animal models and clinical treatments for chronic pain from the leading pain experts.
Intended learning outcomes At the end of the course the students should be able to:
- Identify the major anatomical structures associated with pain transmission from the peripheral through the central nervous system.
- Identify the fundamental biological structural components and pathways of pain signaling from a cellular perspective
- Describe systems and molecular mechanisms that either facilitate or inhibit pain transmission in peripheral or central nervous system.
- Describe current knowledge on sex-based differences in pain signaling or perception in animals and man.
- Categorize the diversity of common pain conditions in patients
- Contrast pre-clinical and clinical models of pain transmission and analgesia.
- Summarize the current pharmacological approaches used for pain management
- Discuss the several non-pharmacological, complementary and alternative techniques that are applied for pain management.

Contents of the course Basic Science Nociceptors, nociception and pain Mediators, receptors, ion channels and intracellular signaling. Dorsal horn structure and function. Ascending nociceptive pathways. Descending inhibition and facilitation. Peripheral and central sensitization. Neuroimmune interactions in chronic pain. Role of glial activation in pain. Genetics of pain and species and sex differences in anatomy, molecular biology and behavior. Genomics and pain. Proteomics and pain. Epigenetic mechanisms of chronic pain. Assessment of pain and nociception, neuroimaging and statistical analysis Overview of clinical pain testing. Placebo and nocebo. Sensory assessment in animals. Neuroimaging and pain. Statistical analysis of preclinical and clinical pain data. Chronic pain in the clinic and animal models Pain classification, nociceptive, neuropathic and nociplastic pain. Chronic pain in the clinic and animal models. Clinical states with inflammatory pain. Animal models of acute and chronic inflammatory pain. Neuropathic pain in the clinic. Animal models of neuropathic pain. Musculoskeletal pain, fibromyalgia. Cancer pain: causes, consequences and Therapeutic opportunities. Animal models of cancer pain. Visceral pain. Headache, migraine, whiplash pain. Pain comorbidities. Treatment of pain Mechanisms of action of established analgesic drugs and targets for new analgesic drugs. Clinical pharmacology of analgesic drugs. Surgical approaches in pain management and CNS stimulation for neuropathic, ischemic and visceral pain. Psychotherapeutic approaches to treat chronic pain. Complementary and alternative therapies for chronic pain.
Teaching and learning activities Lectures, seminars, round table discussions, laboratory demonstrations, clinical demonstrations
Compulsory elements -
Examination The examination for all students will consist of some multiple choice questions from each teacher. In addition, essays and/or project presentations and discussions for all students will be included.
Literature and other teaching material Recently published review and original articles will be provided in digital format. Text book for reference: Wall and Melzack's Textbook of Pain, 6:th Edition, 2013, Edited by Stephen B McMahon, Martin Koltzenburg, Irene Tracey & Dennis C. Turk, Elsevier Churchill Livingstone, ISBN: 978-0-7020-4059-7.
Number of students 10 - 10
Selection of students Priority during the selection will be given: 1) based on motivation letter, 2) to students that have passed half-time review.
More information The course will take place at University of Minnesota, Twin Cities Campus, Molecular & Cellular Biology (MCB) Building, classroom 3-120, 420 Washington Ave SE, Minneapolis, MN, USA.
There is a limited number of travel grants available for KI doctoral students participating in the course. If you wish to apply for such a support please include a motivation for this in your course application.
Additional course leader
Earlier evaluation of the course Not available
Course responsible Camilla Svensson
Institutionen för fysiologi och farmakologi

camilla.svensson@ki.se
Contact person Eva Kosek
Institutionen för klinisk neurovetenskap

Eva.Kosek@ki.se


Vinko Palada
Institutionen för fysiologi och farmakologi

vinko.palada@ki.se