Course catalogue doctoral education - VT19

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Title Clinical methodologies in metabolic research
Course number 3153
Programme Metabolism och endokrinologi
Language English
Credits 1.5
Date 2019-05-13 -- 2019-05-17
Responsible KI department Institutionen för medicin, Huddinge
Specific entry requirements
Purpose of the course This course will enable the doctoral student to acquire and integrate knowledge of clinical and basic methodologies used in human metabolic research. It will promote understanding, competence, skills, judgement and approach in the field of obesity and diabetes mellitus and will facilitate student's development as future scientist, public health specialist and/or clinician in this field.
Intended learning outcomes After the course, students will have acquired a basic understanding of commonly used techniques in clinical and experimental metabolic research and an insight in how to combine analyses of clinical metabolic measurements with data obtained in molecular and cell culture-based methodologies.
Contents of the course The course is based on clinical metabolic studies in human subjects and in vitro studies of human cell metabolism. Students will receive a theoretical introduction to methodologies used in clinical and experimental metabolic research. In addition, they will get demonstrations of common clinical metabolic techniques including clamps, fat/muscle/liver biopsies, determination of body composition (by bioimpedance and DEXA) and arterial stiffness, continuous blood pressure and glucose monitoring, clinical questionnaires as well as assessments of physical activity and sleep quality. Some of the (non-invasive) methods will be practiced by the participants themselves. Students will also be introduced to and perform commonly used experimental techniques, such as gene expression analyses in clinical samples as well as metabolic measurements in cell cultures, e.g. insulin-stimulated glucose uptake and determination of lipid accumulation. Primary human cells will be used as a cell model. Students will be shown how clinical metabolic measures can be linked to results obtained in vitro and vice-versa.
Teaching and learning activities Lectures, group discussions, practical exercises, demonstrations, laboratory sessions.
Compulsory elements Practical exercises, demonstrations and laboratory sessions are compulsory and the absence must be compensated by written assays.
Examination Oral examination where students should describe how they could combine two of the methods they have learned during the week.
Literature and other teaching material 1. Metabolic regulation. A human perspective. Keith N.Frayn, - 3rd edition, 2010. ISBN 978-1-4051-8359-8 2. Protocols and lecture material will be given by the lecturers during the course.
Number of students 8 - 15
Selection of students Selection will be based on 1) the relevance of the course syllabus for the applicant's doctoral project (according to written motivation), 2) date for registration as a doctoral student (priority given to earlier registration date)
More information The course will take place at Karolinska Hospital Huddinge C2:94 and NEO.
Additional course leader Jurga Laurencikiene
Earlier evaluation of the course Not available
Course responsible Daniel P Andersson
Institutionen för medicin, Huddinge

Daniel.P.Andersson@ki.se
Contact person Jurga Laurencikiene
Institutionen för medicin, Huddinge

Jurga.Laurencikiene@ki.se