Course catalogue doctoral education - HT19

  • Ansökan kan ske mellan 2019-04-15 och 2019-05-15
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Title Inherited cancer syndromes; Genes predisposing to malignant disease
Course number 3151
Programme Tumörbiologi och onkologi (FoTO)
Language English
Credits 1.5
Date 2019-04-01 -- 2019-04-05
Responsible KI department Institutionen för molekylär medicin och kirurgi
Specific entry requirements
Purpose of the course Hereditary cancer are associated with germline mutations that lead to increased vulnerability for an individual to develop cancers. These include germline mutations in tumour suppressor genes, oncogenes and genes encoding for proteins in cell cycle control and DNA repair and that cause overall genomic instability and increased risk in developing cancers. The underlying genetic cause can in some cases be utilised in targeted therapy. The purpose of this course is to bring the students to an advanced level in the fast-developing field of hereditary cancer syndromes, and to provide knowledge that can be applied both for basic, pre-clinical and clinical research.
Intended learning outcomes After the course, the students should have knowledge on both more common and rare hereditary cancer syndromes and the genetic mechanisms behind them. The students will have gained skills in drawing and interpreting pedigrees, judging the impact of different cancer diagnoses on the clinical and research diagnostic process and be able to evaluate the evidence for genetic testing for these syndromes as well as for the impact of prevention programs and therapeutic options for hereditary cancer syndromes. The students should be able to critically judge basic research in the above topics for hereditary cancer syndromes as well as their clinical implementation. Students should be able to identify areas for future research as well as suggest appropriate methods to address these issues.
Contents of the course The course will present the latest research into both rare and more common hereditary cancer syndromes including hereditary colorectal cancer, familial melanoma, hereditary breast cancer syndromes, Li-Fraumeni syndrome and other rare forms of inherited cancer.
Teaching and learning activities The course will contain lectures, a seminar on pedigree interpretation and genetic counselling and a workshop on the use of next generation sequencing in research on hereditary cancer syndromes. There will be time for individual work in the afternoons.
Compulsory elements The course seminar as well as the examination are compulsory.
Examination The course assessment will consist of a written exam and an oral individual presentation followed by a discussion.
Literature and other teaching material Reference literature will be recent scientific articles.
Number of students 10 - 25
Selection of students Selection will be based on 1) the relevance of the course syllabus for the applicant's doctoral project (according to written motivation), 2) date for registration as a doctoral student (priority given to earlier registration date)
More information Preliminary course hours: 8:30-16:30. Location: Karolinska University Hospital Solna, L2:U1, room 1
This course has previously been given as 2110.
Additional course leader
Earlier evaluation of the course Evaluation report
Course responsible Emma Tham
Institutionen för molekylär medicin och kirurgi
Contact person Emma Tham
Institutionen för molekylär medicin och kirurgi