Course catalogue doctoral education - HT19

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Title Practical approach to animal models in cardiovascular research
Course number 2877
Programme Kardiovaskulär forskning
Language English
Credits 1.5
Notes A Laboratory Animal Science course.

Date 2019-05-06 -- 2019-05-10
Responsible KI department Institutionen för medicin, Solna
Specific entry requirements Laboratory animal science course equivalent to a FELASA B or FELASA C level (Directive Function A, D - EU Directive 2010/63 art. 23-26). Researchers with education in laboratory animal science from countries other than Sweden need to pass the Swedish legislation, ethics and animal use course before they will be granted access to animal facilities at Karolinska Institutet.
Purpose of the course The purpose of the course is to enable doctoral students to obtain practical experience in models of cardiovascular research as well as to discuss with fellow students and experts in the field the theory of the models and ethical aspects of translation research.
Intended learning outcomes At the end of the course the participant should be able to:
- Know how to develop, and maintain breeding programs for genetically manipulated mice in the most optimal fashion
- Show an understanding on how to maintain experimental mice in order to investigate cardiovascular diseases and obtain maximal data from each experiment
- Show an understanding of the main functional cardiovascular disease models and how to use them
-Understand the benefits and limitations of the cardiovascular disease models that are used
- Be able to practically perform common mouse models for cardiovascular disease
Contents of the course The course is aimed at students who are starting or have just started to use animal models in cardiovascular research. It is designed for students who have done a basic animal course such as FELASA B or C. The course will give theoretical knowledge about how to create genetically manipulated mice, as well as breeding and maintaining mice for optimal use. Furthermore, an incite to other animal models will be given such as pigs and rats. There is also a practical component where students will get hands-on-experience in the most common models used.
Teaching and learning activities The course is partly theoretical, partly practical, where lectures/group discussions and laboratory demonstrations are integrated. Time is also allocated for discussing of laboratory results and lectures.
Compulsory elements Practical sessions are compulsory. Absence from practical sessions cannot be compensated for, but absence from one theoretical session can be compensated for in subsequent sessions.
Examination All the learning outcomes of the course have to be reached to pass the course. The final grade (pass or fail) will be based on: - summative assessment of the contributions during the discussions that are part of the course - individual presentation at a seminar where different aspects of an animal model will be discussed, i.e. disease aspect to be investigated, which model would suit best, and how are the results analyzed and interpreted
Literature and other teaching material Material listed below can be obtained via KI proxy server. Animal Models for the Study of Human Disease http://www.sciencedirect.com.proxy.kib.ki.se/science/book/9780124158948#ancp3 Genetically modified pigs to model human diseases http://link.springer.com.proxy.kib.ki.se/article/10.1007/s13353-013-0182-9/fulltext.html Inflammation and atherothrombosis in Clinical Immunology (Third Edition) http://www.sciencedirect.com.proxy.kib.ki.se/science/article/pii/B9780323044042100685
Number of students 8 - 10
Selection of students Selection will be based on 1) the relevance of the course syllabus for the applicant's doctoral project (according to written motivation), 2) date for registration as a doctoral student (priority given to earlier registration date)
More information We aim for this course to be interative and to some extent custom made. If you have a particular model you are interested in -we will try and get expertise in that model. However, this takes time so please notify me directly at alexandra.backlund@ki.se Students must have completed FELASA B and have been approved into a KI animal house facility. Students will not be able to visit other animal houses other than AKM L5 and L8 during this week.
Additional course leader
Earlier evaluation of the course Evaluation report
Course responsible Alexandra Bäcklund
Institutionen för medicin, Solna

Alexandra.Backlund@ki.se
Contact person Alexandra Bäcklund
Institutionen för medicin, Solna

Alexandra.Backlund@ki.se