Kurskatalog forskarutbildning  HT18

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Titel  Biostatistics I: Introduction for epidemiologists 

Kursnummer  1579 
Program  Epidemiologi 
Språk  Engelska 
Antal högskolepoäng  3.0 
Noteringar 
Kursen uppfyller kraven för en allmänvetenskaplig kurs. 
Datum  20180917  20181008 
Kursansvarig institution  Institutionen för medicinsk epidemiologi och biostatistik 
Särskild behörighet  
Kursens syfte  The aim is to introduce classical statistical concepts and methods with emphasis on methods used in epidemiology and public health. 
Kursens lärandemål  After successfully completing this course students should be able to: define the concept of probability, laws of probability, and make simple probability calculations. (S2) suggest a statistical distribution to describe a naturally occurring phenomonen and evaluate the appropriateness of the distribution given real data. (S3) present appropriate descriptive statistics for an epidemiological study. (S2) explain the difference between hypothesis testing and interval estimation and the relation between pvalues and confidence intervals. (S3) suggest an appropriate statistical test for a comparison of two groups, perform the hypothesis test using standard statistical software, and interpret the results. (S3) estimate and interpret three alternative measures of association between binary exposures and binary outcomes and discuss the relative merits of each measure for a given research question. (S3) explain the concept of confounding in epidemiological studies and demonstrate how to control/adjust for confounding using stratified analysis. (S2) explain the basis of the linear regression model, fit a linear regression model using standard statistical software, assess the fit of the model, and interpret the results. (S2) Learning outcomes are classified according to Bigg's structure of the observed learning outcome (SOLO) taxonomy: (S1) unistructural, (S2) multistructural, (S3) relational, and (S4) extended abstract. 
Kursens innehåll  The course introduces classical statistical concepts and methods with emphasis on methods used in epidemiology and public health. Topics covered include: the importance of statistical thinking; types of data (nominal, binary, discrete and continuous variables); data summary measures; contingency tables; graphical representations; notions of probability; probability models (distributions); principles of statistical inference; parameter estimation (mean, proportion (prevalence), incidence and ratios); concepts of confidence intervals and hypothesis tests; and a general introduction to correlation and linear regression models. 
Arbetsformer  Lectures, exercises focusing on analysis of real data using statistical software, exercises not requiring statistical software, group discussions, literature review. 
Obligatoriska moment  The individual written examinations (summative assessments) are compulsory. 
Examination  The course grade is based on the two written examinations. The course is divided into two parts, and each part will be examined separately. To pass the course, the student must pass both parts. Students who fail will be offered a reexamination within two months of the final day of the course. Students who fail the reexam will be given top priority for admission the next time the course is offered. If the course is not offered during the following two academic terms then another reexamination will be scheduled within 12 months of the final day of the course. 
Kurslitteratur och övriga läromedel  Compulsory texts Kirkwood BR. Essentials of Medical Statistics. 2th ed. John Wiley & Sons; 2003. Recommended texts RabeHesketh S, Everitt BS. A Handbook of Statistical Analyses Using Stata. 4th ed. College Station: Stata Press; 2006. Juul S. An Introduction to Stata for Health Researchers. College Station: Stata Press; 2006. Dawson B, Trapp R. Basic & Clinical Biostatistics. 4th ed. McGrawHill Medical; 2004 Woodard M. Epidemiology: Study Design and Data Analysis. 2nd ed. Chapman & Hall;2004 
Antal studenter  8  25 
Urval av studenter  Eligible doctoral students will be prioritized according to 1) the relevance of the course syllabus for the applicant's doctoral project (according to written motivation), 2) date for registration as a doctoral student (priority given to earlier registration date). Give all information requested, including a short description of current research training and motivation for attending, as well as an account of previous courses taken. Prior knowledge in Stata software is strongly recommended. 
Övrig information  The course is extended over time in order to promote reflection and reinforce learning. The course will be held the dates September 17, 19, 21, 24 and 26 (week 1) and September 28, October 1, 3, 5 and 8 (week 2). The individual examination will be performed as an inclass examination the last course day of each week. Dates for reexamination: October 17 (for week 1), October 24 (for week 2). 
Ytterligare kursledare  
Tidigare omdöme av kursen  omdöme 
Kursansvarig 
Yudi Pawitan Institutionen för medicinsk epidemiologi och biostatistik Yudi.Pawitan@ki.se 
Kontaktpersoner 
Gunilla Nilsson Roos Institutionen för medicinsk epidemiologi och biostatistik 08524 822 93 gunilla.nilsson.roos@ki.se 