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| Titel | Antigen presentation and T cell activation |
|---|---|
| Kursnummer | 2363 |
| Program | Allergi, immunologi och inflammation (Aii) |
| Språk | Engelska |
| Antal högskolepoäng | 1.5 |
| Datum | 2018-11-26 -- 2018-11-30 | Kursansvarig institution | Institutionen för onkologi-patologi |
| Särskild behörighet | Basic immunology course, or otherwise have attained the same level of previous knowledge. |
| Kursens syfte | This course will provide a cutting edge overview of antigen presentation and T cell activation. This course is suitable for PhD students with basic immunology knowledge who want to deepen their knowledge in important aspects of various lymphocyte subsets biology. |
| Kursens lärandemål | By completing this course the students will be able to account for different types of antigen capture and processing, antigen presentation pathways (MHC class I and II), the MR1 and CD1 system, peptide/lipid/glycolipid presentation as well as T-cell subsets and invariant lymphocytes. The students will be able to demonstrate that they have acquired the required knowledge about T lymphocyte recognition of antigen-presentation with strong focus on lymphocyte and target cell. The students will also be able to demonstrate that they have acquired the required knowledge about T-cell activation and the effects of this in steady state or disease as well as in cell therapy. |
| Kursens innehåll | The following will be covered during the course: Antigen capture (including endocytosis, phagocytosis) and some immune evasion strategies related to this. This will be followed by a thorough walk-through of the antigen presentation pathways, both MHC class I and II, and upstream and downstream TCR activation, as well as 2nd signal, and 3rd signal (cytokine) induced T cell activation. The CD1 system, presentation of lipids, glycolipids (including microbial interference, presentation to lymphocytes such as CD1 restricted T cells and NKT cells, lymphocyte mediated regulation of antigen presentation), MR1 presentation and MAIT cell activation will be discussed. Manipulation of T cell activation by checkpoint inhibitors, and practical applications such as vaccination and immunotherapy will also be covered. |
| Arbetsformer | The course will be based on lectures, as well as extra time for follow up discussions. In addition a smaller group work will enable the students to gain deeper knowledge in a small area of interest. The students are also given literature (see below) in order to prepare for the lectures and discussions. |
| Obligatoriska moment | All lectures and group sessions are considered mandatory. Missed events should be compensated for with a written report on the subject in accordance with the indications of the course organizer. |
| Examination | To pass the course, the student has to show that the learning outcomes have been reached. The students will be assessed with a group project presented in a written report, along with individual oral presentations. The focus of the examination is gain of knowledge rather than test of knowledge. |
| Kurslitteratur och övriga läromedel | Review articles and selected articles relevant to the lectures (invited speakers will also be asked to suggest papers), will be distributed prior to the course. Examples: - T cell antigen receptor recognition of antigen-presenting molecules. Annu Rev Immunol. 2015;33:169-200. Rossjohn et al.; - The burgeoning family of unconventional T cells. Nat Immunol. 2015 Nov;16(11):1114-23.Godfrey DI et al.; - Early T cell activation: integrating biochemical, structural, and biophysical cues. Annu Rev Immunol. 2015;33:539-61.Malissen B. |
| Antal studenter | 10 - 20 |
| Urval av studenter | Selection will be based on 1) the relevance of the course syllabus for the applicant's doctoral project (according to written motivation), 2) date for registration as a doctoral student (priority given to earlier registration date) |
| Övrig information | |
| Ytterligare kursledare | |
| Senaste kursvärdering | Kursvärderingsrapport |
| Kursansvarig |
Isabelle Magalhaes Institutionen för klinisk vetenskap, intervention och teknik Isabelle.Magalhaes@ki.se |
| Kontaktpersoner |
Isabelle Magalhaes Institutionen för klinisk vetenskap, intervention och teknik Isabelle.Magalhaes@ki.se |
