Kurskatalog forskarutbildning - VT19

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Titel Antigen presentation and T cell activation
Kursnummer 2363
Program Allergi, immunologi och inflammation (Aii)
Språk Engelska
Antal högskolepoäng 1.5
Datum 2018-11-26 -- 2018-11-30
Kursansvarig institution Institutionen för onkologi-patologi
Särskild behörighet Basic immunology course, or otherwise have attained the same level of previous knowledge.
Kursens syfte This course will provide a cutting edge overview of antigen presentation and T cell activation. This course is suitable for PhD students with basic immunology knowledge who want to deepen their knowledge in important aspects of various lymphocyte subsets biology.
Kursens lärandemål By completing this course the students will be able to account for different types of antigen capture and processing, antigen presentation pathways (MHC class I and II), the MR1 and CD1 system, peptide/lipid/glycolipid presentation as well as T-cell subsets and invariant lymphocytes.
The students will be able to demonstrate that they have acquired the required knowledge about T lymphocyte recognition of antigen-presentation with strong focus on lymphocyte and target cell. The students will also be able to demonstrate that they have acquired the required knowledge about T-cell activation and the effects of this in steady state or disease as well as in cell therapy.
Kursens innehåll The following will be covered during the course: Antigen capture (including endocytosis, phagocytosis) and some immune evasion strategies related to this. This will be followed by a thorough walk-through of the antigen presentation pathways, both MHC class I and II, and upstream and downstream TCR activation, as well as 2nd signal, and 3rd signal (cytokine) induced T cell activation. The CD1 system, presentation of lipids, glycolipids (including microbial interference, presentation to lymphocytes such as CD1 restricted T cells and NKT cells, lymphocyte mediated regulation of antigen presentation), MR1 presentation and MAIT cell activation will be discussed. Manipulation of T cell activation by checkpoint inhibitors, and practical applications such as vaccination and immunotherapy will also be covered.
Arbetsformer The course will be based on lectures, as well as extra time for follow up discussions. In addition a smaller group work will enable the students to gain deeper knowledge in a small area of interest. The students are also given literature (see below) in order to prepare for the lectures and discussions.
Obligatoriska moment All lectures and group sessions are considered mandatory. Missed events should be compensated for with a written report on the subject in accordance with the indications of the course organizer.
Examination To pass the course, the student has to show that the learning outcomes have been reached. The students will be assessed with a group project presented in a written report, along with individual oral presentations. The focus of the examination is gain of knowledge rather than test of knowledge.
Kurslitteratur och övriga läromedel Review articles and selected articles relevant to the lectures (invited speakers will also be asked to suggest papers), will be distributed prior to the course. Examples: - T cell antigen receptor recognition of antigen-presenting molecules. Annu Rev Immunol. 2015;33:169-200. Rossjohn et al.; - The burgeoning family of unconventional T cells. Nat Immunol. 2015 Nov;16(11):1114-23.Godfrey DI et al.; - Early T cell activation: integrating biochemical, structural, and biophysical cues. Annu Rev Immunol. 2015;33:539-61.Malissen B.
Antal studenter 10 - 20
Urval av studenter Selection will be based on 1) the relevance of the course syllabus for the applicant's doctoral project (according to written motivation), 2) date for registration as a doctoral student (priority given to earlier registration date)
Övrig information
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Kursansvarig Isabelle Magalhaes
Institutionen för onkologi-patologi

Isabelle.Magalhaes@ki.se
Kontaktpersoner Isabelle Magalhaes
Institutionen för onkologi-patologi

Isabelle.Magalhaes@ki.se