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| Titel | Brain circuits |
|---|---|
| Kursnummer | 2624 |
| Program | Neurovetenskap |
| Språk | Engelska |
| Antal högskolepoäng | 1.5 |
| Datum | 2018-09-17 -- 2018-09-21 | Kursansvarig institution | Institutionen för neurovetenskap |
| Särskild behörighet | |
| Kursens syfte | The purpose of the course is to provide doctoral students in the field of neuroscience with an overview of current state-of-the art approaches, technologies and concepts used for understanding of the brain's circuits and functions in animal models. All invited speakers have made seminal contributions to how we currently study and understand the brain, and there will be ample opportunities for the students to interact with the speakers, and discuss aspects relevant to their own work. |
| Kursens lärandemål | By the end of the course the student shall be able to: - explain the structure and function of the main brain circuits, - describe the principles for excitatory and inhibitory networks, including receptors and neurotransmitters, as well as the action of different chemical neuromodulators, - describe principles, use and readout of optogenetics and recording technologies, - describe principles and methods to define the structure (neuroanatomy) of brain circuits, - explain how dysfunctions of networks can manifest as neuropsychiatric disorders, - describe animal behavior tests probing specific networks and network functions. |
| Kursens innehåll | The course will cover the organization and function of main circuits in the brain, including the interaction and participation of different cell types, the interplay between excitation and inhibition, and how circuit output results in behavior. Different techniques for recording, labeling and manipulation of neuronal circuits in animal models will be discussed, including electrophysiology, molecular targeting, optogenetics and viral tracing. The connection between deficient circuit functions and neuropsychiatric disorders will be included, as well as animal behavior tests probing specific circuits and circuit (dys)functions. Specific emphasis will be put into describing the technologies currently used in the neuroscience field. |
| Arbetsformer | Lectures by invited experts and group exercises. |
| Obligatoriska moment | The seminar presentations are obligatory, and so are all lectures. Any absence has to be compensated for in accordance with the instructions of the course director. |
| Examination | The student should in discussions and a seminar presentation demonstrate the ability to critically evaluate original research papers on the topics covered and be able to show that the intended learning outcomes for the course are reached. |
| Kurslitteratur och övriga läromedel | Original research and review papers provided by the course organizers. |
| Antal studenter | 12 - 24 |
| Urval av studenter | We welcome highly motivated applicants from all areas of neuroscience. Knowledge of how neurons function and of brain anatomy is a prerequisite. Selection will be based on 1) the relevance of the course syllabus for the applicant's doctoral project according to the written motivation in the application, 2) date for registration as a PhD student (priority given to earlier reg. date), 3) experience of neuroscience research as stated in the written motivation. |
| Övrig information | The course will be given at Karolinska Institutet, campus Solna. Time: 9.00-17.00 (Monday to Friday). Lectures will be given by international and national scientists who have made significant contributions to their respective field, including development or application of novel technologies. We have a strong emphasis on young scientists, and rodent basic neuroscience studies. Confirmed teachers: Anton Sirota (University of Munich), Karl Deissoroth (Stanford University, USA), Carl Petersen (EPFL, Switzerland) Peter Magill (Oxford University), Gilad Silberberg (KI), Laura Busse (University of Munich), Daniel Huber (University of Geneva), Koen Vervaeke (Oslo University) and more. |
| Ytterligare kursledare | Konstantinos Meletis |
| Senaste kursvärdering | Kursvärderingsrapport |
| Kursansvarig |
Marie Carlen Institutionen för neurovetenskap 08-52483043 Marie.Carlen@ki.se |
| Kontaktpersoner |
Mikael Corell Ej satt mikael.corell@ki.se |
