Kurskatalog forskarutbildning - VT24
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| Titel | Health risk assessment of reproductive toxicity and endocrine disruptors |
|---|---|
| Kursnummer | 2933 |
| Program | X- Används inte längre - Miljöfaktorer och hälsa |
| Språk | Engelska |
| Antal högskolepoäng | 1.5 |
| Datum | 2018-09-24 -- 2018-09-28 | Kursansvarig institution | Institutet för miljömedicin |
| Särskild behörighet | |
| Kursens syfte | The purpose of the course is to give the student knowledge and understanding of how to assess health risks of chemical substances that cause reproductive toxicity including endocrine disruptors. |
| Kursens lärandemål | After the completion of the course the student shall be able to: - describe the principles for health risk assessment of reproductive toxicity - explain how different types of data from in vivo, epidemiological and in vitro studies are used for health risk assessment of reproductive toxicity - identify and discuss complexities in health risk assessment of reproductive toxicity - identify and discuss complexities in health risk assessment of endocrine disruptors |
| Kursens innehåll | Reproductive toxicity describes toxic effects of a chemical substance on the reproductive ability as well as on the development of the offspring. Health risk assessment of reproductive toxicity addresses the procedures to identify and characterise the reproductive toxicity with the aim to derive health based guidance values for safe levels of the chemical substances. Endocrine disruptors are substances that alter the endocrine system and are a special concern for risk assessment of reproductive toxicity. The course introduces the concepts in reproductive toxicity as well as of endocrine disruptors. Methods for identification and assessment of reproductive toxicity are described and discussed. Regulatory aspects of reproductive toxicity and endocrine disruption will be covered. Attention will be paid to evaluation of different type of data. Specific challenges in risk assessment of reproductive toxicity and of endocrine disruptors such as non-monotone dose response curves, low-dose effects and epigenetic mechanisms will be discussed. |
| Arbetsformer | Teaching and learning activities include lectures, exercises and group assignments. |
| Obligatoriska moment | Participation in the exercises and group assignments is compulsory. Absence can be compensated with an individual task. |
| Examination | Examination is in the form of a written assignment and/or oral presentation. |
| Kurslitteratur och övriga läromedel | Reports and guidelines from international organisations as well as scientific publications. |
| Antal studenter | 8 - 20 |
| Urval av studenter | Selection will be based on 1) the relevance of the course syllabus for the applicant's doctoral project (according to written motivation), 2) date for registration as a doctoral student (priority given to earlier registration date) |
| Övrig information | |
| Ytterligare kursledare | Course directors: Johanna Zilliacus and Annika Hanberg, Institute of Environmental Medicine (IMM), Karolinska Institutet. |
| Senaste kursvärdering | Kursvärderingsrapport |
| Kursansvarig |
Johanna Zilliacus Institutet för miljömedicin 08 52483544 Johanna.Zilliacus@ki.se |
| Kontaktpersoner | - |
