Course catalogue doctoral education - VT19

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Title Neurodegenerative disorders II - cellular and molecular mechanisms
Course number 2630
Programme Neurovetenskap
Language English
Credits 1.5
Date 2018-10-15 -- 2018-10-19
Responsible KI department Institutionen för neurobiologi, vårdvetenskap och samhälle
Specific entry requirements The course is a continuation of the course Neurodegenerative disorders I, From molecule to treatment, but it can also be taken as a separate course, provided the participant has in other ways achieved the learning outcomes of that course.
Purpose of the course The purpose of the course is to provide a deeper understanding of neurodegenerative disorders, focusing on molecular mechanisms and techniques used for studying these, as well as treatment strategies.
Intended learning outcomes The student should:
- be able to understand and critically evaluate relevant cellular and molecular pathophysiological mechanisms of neurodegenerative disorders such as stroke, Alzheimer disease, frontotemporal dementia, Lewy body disease, Parkinson´s disease, multiple sclerosis, amyotrophic lateral sclerosis, and the mechanisms of current and/or possible future treatments.
- be able to understand and to perform important methods and assays for studying mechanisms behind neurodegenerative disorders, and discuss the results, taking into account the limitations of the assays.
- be able to discuss the present disease models, propose alternative models, and critically evaluate these models from the perspectives of a) clinical picture, b) disease mechanisms, and c) treatment mechanisms.
Contents of the course The course addresses topics in basic and clinical research on neurodegenerative disorders. The focus will be on a deeper understanding of cellular and molecular mechanisms, and the techniques to study them. To this end, the students will learn about some powerful techniques that can be used for studying neurodegeneration, subcellular localization, and elucidation of pathogenic pathways.
Teaching and learning activities The course runs daytime for 1 week full-time with some key lectures by invited scientists, laboratory practicals, and discussions in small groups and the entire class.
Compulsory elements The student is obliged to attend 80% of the lectures, all laboratory practicals, and the exam (including the group discussion after the exam). Students that are absent from the practicals and/or more than 20% of the lectures will have to submit a written presentation of the subjects missed.
Examination Oral examination followed by group discussions on the examination questions, and a general discussion between all participants.
Literature and other teaching material Scientific articles and hand-outs distributed by the course organizers and lecturers.
Number of students 10 - 24
Selection of students Selection will be based on 1) the relevance of the course syllabus for the applicant's doctoral project (according to written motivation), 2) date for registration as a doctoral student (priority given to earlier registration date)
More information The course is given at the Department of Neurobiology, Care Sciences and Society, Division of Neurogeriatrics, Bioclinicum.
Additional course leader Lars Tjernberg, Per ET Nilsson
Earlier evaluation of the course Evaluation report
Course responsible Sophia Schedin Weiss
Institutionen för neurobiologi, vårdvetenskap och samhälle

sophia.schedin.weiss@ki.se
Contact person Per Nilsson
Institutionen för neurobiologi, vårdvetenskap och samhälle

Per.et.Nilsson@ki.se


Lars Tjernberg
Institutionen för neurobiologi, vårdvetenskap och samhälle

Lars.Tjernberg@ki.se