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Title Cancer Cell Metabolism
Course number 3076
Programme Tumörbiologi och onkologi (FoTO)
Language English
Credits 1.5
Date 2018-11-05 -- 2018-11-09
Responsible KI department Institutionen för mikrobiologi, tumör- och cellbiologi
Specific entry requirements Basic knowledge in Tumor Cell Biology
Purpose of the course The course provides an introduction to cancer cell metabolism. Focus is on the roles of oncogenic signaling and tumor microenvironment as drivers of tumor development and progression. Therapeutic and diagnostic perspectives exploiting the altered cancer metabolism are discussed.
Intended learning outcomes After the course, the student should be able to:
- describe and explain the role of altered cellular metabolism in cancer development and cancer progression;
- reflect upon the interaction between oncogenic signaling and tumor metabolism;
- discuss how tumor metabolism may be exploited in anticancer therapies and diagnosis/prognosis.
Contents of the course Overview about cell metabolism
The major metabolic pathways
The mitochondrion
Signalling pathways and metabolic control
Cancer cell metabolism
Methods to study cell metabolism
Targeting metabolism for cancer treatment
Teaching and learning activities The course consists of lectures with invited national and international scientists with focus on Cancer cell Metabolism. The students will actively talk to the scientists in the ""Meet the Scientists"" format and discuss the topics during beehive discussions. The course is given full-time during 1 week. The teaching is mainly in lecture/seminar form and also includes project work. This project is presented orally on the last day of the course. The project work requires studies of a specific topic in Cancer Cell Metabolism.

Compulsory elements Attendance at lectures is strongly advised. Participation in the beehive and ""Meet the scientists"" session is mandatory. To compensate for absence due to e.g. illness the student may be required to write a report and/or discuss the missed subject with the course leaders.
Examination Examination is divided into two parts: Firstly, during active participation in the ""Meet the scientists"" seminar and in connection with the beehive group discussion. Secondly, the students will be given an assignment to be presented on the last day of the course. This assignment is a short project proposal within one topic chosen from a list of 10. The proposal will contain an overview of the field which motivates a specific research question identified by the student/s and a brief work plan that explains how the question/hypothesis can be solved/investigated.
Literature and other teaching material Literature suggestions will be made by the lecturers during the course. In addition, this is a list of suggested literature Cairns RA, Harris IS, Mak T. Regulation of cancer cell metabolism. Nat Rev Cancer 2011 Schulze A and Harris AL. How cancer metabolism is tuned for proliferation and vulnerable to disruption. Nature 2012 Ward PS, Thompson CB. Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate. Cancer Cell 2012 Galluzzi L, Kepp O, Vander Heiden MG, Kroemer G. Metabolic targets for cancer therapy. Nat Rev Drug Discov 2013 Parks SK, Chiche J, Pouyssegur J. Disrupting proton dynamics and energy metabolism for cancer therapy. Nat Rev Cancer 2013
Number of students 12 - 25
Selection of students Selection will be based on 1) the relevance of the course syllabus for the applicant's doctoral project (according to written motivation), 2) date for registration as a doctoral student (priority given to earlier registration date)
More information The course will be given full-time during five days. During four days, the students will have two lectures in the morning with a small break in between. After lunch, the students will be presented with some cases or small problems related to the topic of cancer metabolism, that they will need to think about and solve. The rest of the time they will work on the preparation of their final presentation individually or in groups of two people. The last day of the course, the students will attend a mini-symposium with invited international speakers outstanding in the area of cancer metabolism. After the talks, they will have the opportunity to discuss with the speakers about their topics of research. In the afternoon, the students will present their own final work.
Additional course leader Course responsibles: Prof. Marie Arsenian Henriksson and Dr María Victoria Ruiz Pérez
Latest course evaluation Not available
Course responsible Marie Arsenian-Henriksson
Institutionen för mikrobiologi, tumör- och cellbiologi

Marie.Arsenian.Henriksson@ki.se
Contact person María Ruiz Pérez
Institutionen för mikrobiologi, tumör- och cellbiologi

maria.ruiz.perez@ki.se