Kurskatalog forskarutbildning - HT18

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Titel Basic immunology
Kursnummer 2302
Program Allergi, immunologi och inflammation (Aii)
Språk Engelska
Antal högskolepoäng 3.0
Datum 2018-09-24 -- 2018-10-26
Kursansvarig institution Institutionen för medicin, Solna
Särskild behörighet
Kursens syfte To give doctoral students a solid knowledge and understanding of fundamental principles in immunology. All other courses in the doctoral education program Aii (Allergy, immunology and inflammation) assume that students have taken the Basic Immunology course, or otherwise have attained the same level of previous knowledge and understanding.
Kursens lärandemål To be able to understand basic principles of innate and adaptive immunity and how different components of the immune system cooperate. To be able to relate, compare and understand experimental aspects of immune-related diseases in a clinical perspective. To be able to apply knowledge gained on the function of the immune system to analyze and discuss an immunological/clinical case (group project). To be able to present the group project and discuss the results as well as work in pairs with clinical cases.
Kursens innehåll The course is separated into two parts. In part 1 we discuss basic immunological mechanisms within the innate and adaptive immune response. In part 2 we apply the knowledge in clinical settings such as defense against infection, autoimmune and allergic diseases or transplantation. Part 1: An overview of the immune system, T cells, B cells, Antigen presenting cells, Innate lymphoid cells, Innate vs adaptive immune responses. Part 2: Immune defense against bacterial and viral infections, Primary immunodeficiencies, Autoimmune disease, Allergy, Vaccination, Clinical Immunology, Transplantation, Tumor Immunology. Questions and discussions. Presentation of projects.
Arbetsformer The course is given during two weeks separated into two parts. Lectures and seminars are given three days per week and remaining days are assigned for project work, a written assignment as well as reading. The project work and written assignment require studies between the two course parts, including meetings with mentors. On the last day of the course the project work will be presented orally. Course literature (Abbas) is handed out at the course start. An immunological quiz is connected to the different chapters in the book, so that the student will be able to digest the relatively big material. The purpose of dividing the course into two parts is that the participants should have time to thoroughly study the literature from part 1 (fundamental immunological mechanisms) before teaching of the applied immunology in part 2 starts.
Obligatoriska moment All activities included in the course are compulsory. Absence needs to be compensated for in agreement with the course director.
Examination The student will be examined on both the project work and the written assignment. The project work will be evaluated by the group project mentor and by the course organizers during the oral presentations of the work. At this occasion special attention is given to all students' active participation and contributions to the discussions. The individual written assignment is evaluated by the course organizers and, with respect to proposing new research ideas related to the students´ own PhD projects, by their own supervisors.
Kurslitteratur och övriga läromedel Abul Abbas and Andrew Lichtman: Basic Immunology. (Saunders Elsevier). The book is free and is handed out at the course start. Lecture handouts uploaded to the course website. Scientific review articles proposed by group project mentors.
Antal studenter 12 - 50
Urval av studenter Selection will be based on 1) the relevance of the course syllabus for the applicant's doctoral project (according to written motivation), 2) date for registration as a doctoral student (priority given to earlier registration date).
Övrig information The course is divided into two sessions with 3 days of lectures each, September 24th to 26th (Monday to Wednesday) and October 24th to 26th (Wednesday to Friday). In between these days of lectures the students work on both a group project and an individual written assignment, including meetings with mentors and literature studies. The first meeting with mentors should ideally take place on either the 27th or 28th of September (Thursday or Friday, respectively), so students are expected to have time to devote to the course outside the official lecture days. The course location is at the Center for Molecular Medicine (CMM), Karolinska University Hospital, Solna.
Ytterligare kursledare Teachers include specialists in different fields of immunology including both basic and clinical researchers.

Andre Ortlieb Guerreiro Cacais, Organizer
Department of Clinical Neuroscience
Neuroimmunology Unit, CMM, L8:04
Karolinska University Hospital
0730314997
Andre.Ortlieb@ki.se

Susanna Brauner, Co-organizer
Department of Clinical Neuroscience
Neuroimmunology Unit, CMM, L8:04
Karolinska University Hospital
Susanna.Brauner@ki.se
Tidigare omdöme av kursen omdöme
Kursansvarig Andre Ortlieb
Institutionen för klinisk neurovetenskap

Andre.Ortlieb@ki.se
Kontaktpersoner Susanna Brauner
Institutionen för klinisk neurovetenskap

Susanna.Brauner@ki.se