Course catalogue doctoral education - VT19

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Title Endothelial cell function and its relevance in cardiovascular disease
Course number 1710
Programme Kardiovaskulär forskning
Language English
Credits 1.5
Date 2018-11-05 -- 2018-11-09
Responsible KI department Institutionen för medicin, Solna
Specific entry requirements
Purpose of the course This course will enable the participants to obtain the required knowledge to understand and study endothelial cell function in cardiovascular disease.
Intended learning outcomes Upon completion of the course, the students should be able to:
1. show an in depth knowledge of endothelial cell function and related molecular basis;
2. evaluate endothelial cell dysfunction and its relevance to cardiovascular disease (e.g. atherosclerotic lesion, diabetes, ischemia and infection);
3. show an insight into the application of state of the art models and technologies (in vitro, in vivo, from animal model to clinic study) for studying endothelial cell function in cardiovascular disease.
Contents of the course Endothelial cells and endothelial cell function under various physiological and pathological conditions will be discussed from molecular, cellular, organ and clinical perspectives. Topics to be covered include the roles of endothelial cells in atherosclerosis, ischemic heart disease, inflammation, hypertension and diabetes/insulin resistance, and in mechanisms of current and future treatment, The course will include examples of in vitro and animal models for evaluation of endothelial cell function as well as examples of clinical studies.
Teaching and learning activities The course activities include daily interactive lectures and seminars given by invited scholars in the respective fields, lab demonstrations, group learning (literature review and research planning), and a group project presentation and review on the last day of the course.
Compulsory elements Students need to participate in all learning activities and to complete self learning assignments. Absence maybe compensated for by an extra task in agreement with the course organizer. The final examination must be passed in order to get approval of the course.
Examination The final assessment will be held in two parts: 1) a literature review and discussion in groups; 2) a presentation of a research project, which should be designed at least partially using the knowledge from the course lectures and experimental methods from the lab demonstration.
Literature and other teaching material Recommended literature: The importance of endothelin-1 for vascular dysfunction in cardiovascular disease. Böhm F, Pernow J. Cardiovasc Res. 2007 Oct 1;76(1):8-18. Epub 2007 Jun 16. Review. Arginase as a potential target in the treatment of cardiovascular disease: reversal of arginine steal? Pernow J, Jung C. Cardiovasc Res. 2013 Jun 1;98(3):334-43. doi: 10.1093/cvr/cvt036. Epub 2013 Feb 14. Review.
Number of students 8 - 20
Selection of students Selection will be based on: 1) field of study (priority given to cardiovascular, metabolic and inflammatory disease fields) 2) PhD registration date (priority given to earlier registration date) 3) written motivation to attend the course
More information
Additional course leader
Earlier evaluation of the course Evaluation report
Course responsible Jiangning Yang
Institutionen för medicin, Solna

Jiangning.Yang@ki.se
Contact person Jiangning Yang
Institutionen för medicin, Solna

Jiangning.Yang@ki.se