Course catalogue doctoral education - VT24

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Title Multifactorial immune mediated diseases - etiology and pathogenesis
Course number 2532
Programme Allergi, immunologi och inflammation (Aii)
Language English
Credits 1.5
Date 2018-10-01 -- 2018-10-05
Responsible KI department Institutionen för medicinsk biokemi och biofysik
Specific entry requirements Basic knowledge in immunology corresponding to course 2302 is required
Purpose of the course This course gives an overview of multifactorial immune mediated diseases and will take up basic clinical aspects and disease mechanisms. It will also provide opportunity for the student to synthesise their new knowledge in group discussions and with experts in the field.
Intended learning outcomes After completion of the course the students should be able to explain the term multifactorial immune mediated diseases (e.g. allergic, autoimmune, and inflammatory) and discuss basic clinical characteristics and disease mechanisms. They should be able to discuss the role of environment and genes in the etiology of such diseases, and in particular that the diseases are genetically complex. The students should also be able to describe some genetic strategies aimed at identifying risk genes. They should be able to explain how identification of risk genes can give insight into disease pathways, and discuss how such knowledge may enable disease prevention and therapy.
Contents of the course The course includes an overview on chronic immune mediated multifactorial diseases and the challenge they represent to medicine. It covers topics such as clinical characteristics, suggested or known disease mechanisms and genetics including experimental animal models available to study such multifactorial and polygenetic diseases. Key concepts and techniques within each topic will be introduced.
Teaching and learning activities Each day, the course combines a set of overview lectures on clinical diseases followed by lectures on pre-clinical experimental models. Everyday afternoon a group discussion will be held based on previously provided publication (one per day), at group level to facilitate peer learning. One to two senior scientists will facilitate the discussion by providing specific questions related to the publication. The tasks generally consists of ""scientific projects"" that are pursued by combining knowledge acquired during lectures with information available in the literature.
Compulsory elements All lectures, seminars and group- or individual- tasks are compulsory. Compensation for absence can be discussed with the course director.
Examination Examination is based on interactive engagement during daily discussions in the afternoon sessions on all days. During the last day, each student should prepare, present and discuss questions (minimum: 3-5) based on earlier presentations and published papers given during the course with their group members (peer-learning), which will be facilitated by two senior scientists. Apart from the oral presentation to pass the course, a written assignment of two pages connecting the lectures with their own work will be asked from all the participants. Participants should send this written assignment within 5 working days after the last date of the course.
Literature and other teaching material Course literature consists of lecture handouts and selected scientific publications given during the course. In addition, the following books are recommended but not compulsory:
Human Molecular Genetics (2010), by Strachan and Read or later editions
Janeway's immunobiology (2012) eight edition, Kenneth Murphyp; Paul Travers; Mark Walport; Charles Janeway

Above-mentioned books are available in the Karolinska Institutet Library.
Number of students 8 - 15
Selection of students Selection will be based on 1) the relevance of the course syllabus for the applicant's doctoral project (according to written motivation), 2) date for registration as a doctoral student (priority given to earlier registration date)
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Course responsible Amit Saxena
Institutionen för medicinsk biokemi och biofysik

amit.saxena@ki.se
Contact person Liselotte Bäckdahl
Institutionen för medicinsk biokemi och biofysik

Liselotte.Backdahl@ki.se