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| Titel | Imaging in neuroscience: with a focus on structural MRI methods |
|---|---|
| Kursnummer | 3064 |
| Program | Neurovetenskap |
| Språk | Engelska |
| Antal högskolepoäng | 1.5 |
| Datum | 2018-11-26 -- 2018-11-30 | Kursansvarig institution | Institutionen för neurobiologi, vårdvetenskap och samhälle |
| Särskild behörighet | |
| Kursens syfte | The main purpose of the course is to provide the students with a solid understanding of the tools available to analyze brain structural data measured with structural magnetic resonance imaging (sMRI). The students will develop the ability to critically review results provided by different methods, to select the most adequate tools and experimental designs to answer different questions and to compare their relative advantages . |
| Kursens lärandemål | After attending the course the graduate student should be able to: -explain how MR images are generated, what causes artifacts and how to control for them -understand how MRI is used today for dementia investigations -formulate the basics of surface-based analysis and voxel-based morphometry (differences, similarities and quality control etc.) -formulate the basis for multivariate data analysis using structural data in combination with other type of data -formulate the basis for network analysis (using graph theory) using structural data in combination with other types of data -give an overview of different methods for analyzing DTI as well as other imaging modalities |
| Kursens innehåll | The course focuses on neurodegenerative disorders and in vivo measurements of brain structure. The fundamentals of digital image processing will be introduced together with an overview of basic MRI physics, including noise and inhomogeneities as well as optimization of pulse sequences. The course covers the methodological approach to computerized segmentation of MRI anatomy using both surface-based and voxel-based methods. We will also present how MRI is used today in clinical practice to aid the diagnosis of dementia. Further, we will discuss methods for studying white matter integrity (DTI) and function (fMRI). Various approaches to assess the validity and reliability of the gained results will be discussed. Furthermore advanced methods (multivariate data analysis and graph theory) to analyze structural as well as functional data in combination with other type of data (demographic, cognitive and other biomarker data) will be covered. |
| Arbetsformer | Lectures, seminars and workshops for 5 full consecutive days. The students will perform group projects including a critical assessment of relevant scientific literature. |
| Obligatoriska moment | All parts of the course are mandatory. Absence from lectures can be compensated for by a written assignment. A missed seminar or workshop has to be compensated for at a later course occasion. |
| Examination | The examination takes the form of a critical, in-depth discussion of the group project works, where a topic relevant to brain morphometry has been studied via a review of the scientific literature. Students will be individually assessed regarding their ability to discuss their own and others' group work in relation to the intended learning outcomes of the course. |
| Kurslitteratur och övriga läromedel | Recommended: Basic MRI http://www.cis.rit.edu/htbooks/mri/ Books Neuroimaging in Dementia Barkhof, F., Fox, N.C., Bastos-Leite, A.J., Scheltens, P. ISBN 978-3-642-00818-4 Brain Mapping The Systems Arthur W. Toga & John C. Mazziotta ISBN 0-12-692545-3 |
| Antal studenter | 15 - 20 |
| Urval av studenter | Selection will be based on 1) the relevance of the course syllabus for the applicant's doctoral project (according to written motivation), 2) date for registration as a doctoral student (priority given to earlier registration date) |
| Övrig information | The course will be in Campus Flemingsberg, KI, every day of the week (26/11-30/11-2018) 9.00-16.00. The exact location will be announced before the course starts. |
| Ytterligare kursledare | Daniel Ferreira (daniel.ferreira.padilla@ki.se) |
| Senaste kursvärdering | Not available |
| Kursansvarig |
Eric Westman Institutionen för neurobiologi, vårdvetenskap och samhälle 524 83 540 Eric.Westman@ki.se |
| Kontaktpersoner |
Maria Klein Institutionen för neurobiologi, vårdvetenskap och samhälle Maria.Klein@ki.se Daniel Ferreira Padilla Institutionen för neurobiologi, vårdvetenskap och samhälle daniel.ferreira.padilla@ki.se |
