Kurskatalog forskarutbildning - HT18

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Titel Principles of cellular metabolism
Kursnummer 2851
Program Metabolism och endokrinologi
Språk Engelska
Antal högskolepoäng 1.5
Datum 2018-03-12 -- 2018-03-23
Kursansvarig institution Institutionen för medicin, Solna
Särskild behörighet
Kursens syfte The course is intended to give a solid theoretical foundation for studying cellular metabolism from a physical, quantitative perspective, enabling the student to critically approach literature in the field, and serving as a preparation for more specialized courses.
Kursens lärandemål After completing the course, the student should understand the principles underlying the organization of metabolic pathways in human cells; be able to critically evaluate literature and data on cellular metabolism; understand current methods for measuring cellular metabolism; and have a solid foundation to enable deeper study of metabolism independently.
Kursens innehåll The fundamental organization of cellular metabolism; physical constraints on metabolism; important building blocks of metabolic pathways and their properties; major metabolites in human cells; carbohydrate metabolism; amino acid metabolism; nucleotide metabolism; lipid metabolism (briefly); principles of enzyme catalysis and bioenergetics of metabolic pathways; genomic organization of enzymes; properties of metabolic networks; metabolic fluxes and flux balance analysis; catabolism during nutrient starvation; anabolism in proliferating cells; methods for measuring metabolism, in particular isotope tracing; experimental considerations when studying metabolism in cell systems.
Arbetsformer The course will utilize a problem-based learning model with "flipped classroom" techniques, interactive seminars, problem-solving in groups, oral presentations, and individual assignments. Computer labs are included to study metabolic networks and metabolic flux analysis.
Obligatoriska moment Presence on seminars and computer labs is mandatory. Absence must be compensated for by a written resume.
Examination Knowledge is assessed by performance in connection to seminars (comments, questions, answers), performance on computer labs, and an individual home assignment (problem solving / essay) with a short individual oral presentation.
Kurslitteratur och övriga läromedel Berg, Tymoczko, Stryer: Biochemistry (6th ed or later). Scientific articles and other handouts. Tutorials and worked examples on metabolic networks and metabolic flux analysis.
Antal studenter 15 - 20
Urval av studenter Selection will be based on 1) the relevance of the course syllabus for the applicant's doctoral project (according to written motivation), 2) date for registration as a doctoral student (priority given to earlier registration date).
Övrig information The course will run at half speed, distributed over two weeks. The course includes own study time (video lectures) and five half-­day seminars.
Ytterligare kursledare
Tidigare omdöme av kursen omdöme
Kursansvarig Roland Nilsson
Institutionen för medicin, Solna

roland.nilsson@ki.se
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