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Title | Principles of cellular metabolism |
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Course number | 2851 |
Programme | Metabolism och endokrinologi |
Language | English |
Credits | 1.5 |
Date | 2018-03-12 -- 2018-03-23 | Responsible KI department | Institutionen för medicin, Solna |
Specific entry requirements | |
Purpose of the course | The course is intended to give a solid theoretical foundation for studying cellular metabolism from a physical, quantitative perspective, enabling the student to critically approach literature in the field, and serving as a preparation for more specialized courses. |
Intended learning outcomes | After completing the course, the student should understand the principles underlying the organization of metabolic pathways in human cells; be able to critically evaluate literature and data on cellular metabolism; understand current methods for measuring cellular metabolism; and have a solid foundation to enable deeper study of metabolism independently. |
Contents of the course | The fundamental organization of cellular metabolism; physical constraints on metabolism; important building blocks of metabolic pathways and their properties; major metabolites in human cells; carbohydrate metabolism; amino acid metabolism; nucleotide metabolism; lipid metabolism (briefly); principles of enzyme catalysis and bioenergetics of metabolic pathways; genomic organization of enzymes; properties of metabolic networks; metabolic fluxes and flux balance analysis; catabolism during nutrient starvation; anabolism in proliferating cells; methods for measuring metabolism, in particular isotope tracing; experimental considerations when studying metabolism in cell systems. |
Teaching and learning activities | The course will utilize a problem-based learning model with ""flipped classroom"" techniques, interactive seminars, problem-solving in groups, oral presentations, and individual assignments. Computer labs are included to study metabolic networks and metabolic flux analysis. |
Compulsory elements | Presence on seminars and computer labs is mandatory. Absence must be compensated for by a written resume. |
Examination | Knowledge is assessed by performance in connection to seminars (comments, questions, answers), performance on computer labs, and an individual home assignment (problem solving / essay) with a short individual oral presentation. |
Literature and other teaching material | Berg, Tymoczko, Stryer: Biochemistry (6th ed or later). Scientific articles and other handouts. Tutorials and worked examples on metabolic networks and metabolic flux analysis. |
Number of students | 15 - 20 |
Selection of students | Selection will be based on 1) the relevance of the course syllabus for the applicant's doctoral project (according to written motivation), 2) date for registration as a doctoral student (priority given to earlier registration date). |
More information | The course will run at half speed, distributed over two weeks. The course includes own study time (video lectures) and five half-day seminars. |
Additional course leader | |
Latest course evaluation | Course evaluation report |
Course responsible |
Roland Nilsson Institutionen för medicin, Solna roland.nilsson@ki.se |
Contact person | - |