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Title Basic Immunology
Course number 3038
Programme Allergi, immunologi och inflammation (Aii)
Language English
Credits 3.0
Date 2018-01-16 -- 2018-03-08
Responsible KI department Institutionen för mikrobiologi, tumör- och cellbiologi
Specific entry requirements
Purpose of the course The student will learn basic concepts in Immunology and meet the Immunology faculty at Karolinska Institutet. This course is a good starting point for more advanced courses in Immunology.
Intended learning outcomes To understand basic principles of innate and adaptive immunity and how different components of the immune system cooperate.
To be able to relate, compare and understand experimental aspects of immune-related disease in a clinical perspective.
To adapt knowledge gained of the function of the immune system by being able to analyze and discuss an immunological/clinical case (group project).
To present the group project and discuss the results as well as work in pairs with clinical cases.
Contents of the course The course is separated into two parts. In part 1 we discuss basic immunological mechanisms within the innate and adaptive immune response. In part 2 we apply the knowledge in clinical settings such as defence against infection, autoimmune and allergic disease or transplantation.

Part 1:
Introduction
An overview of the immune system
T cells
B cells
Antigen-presenting cells
Innate vs adaptive immune responses
Methods to study immune reactions.

Part 2:
Immune defence against bacterial and viral infections
Primary immunodeficiencies
Autoimmune disease
Allergy
Vaccination
Clinical Immunology
Transplantation
Tumour Immunology
Questions and discussions
Presentation of projects.
Teaching and learning activities The course is given full-time during a total of six days separated into two parts. The teaching is mainly in lecture/seminar form but also includes project work studying cases individually and pairwise, as well as in small groups. The group projects are then presented orally on the last day of the course. The project work requires studies between the two course parts, including meetings with mentors. Course literature (Abbas) and cases are handed out at the course start. An immunological quiz is connected to the different chapters in the book so that the student will be able to digest the relatively big material.
The course is designed so that clinically active doctors will be better able to combine it with work in the clinic (Mondays and Fridays contain no scheduled course work) .The purpose of dividing the course into two parts is that the participants should have time to thoroughly study the literature from part 1 (fundamental immunological mechanisms) before teaching of the applied immunology in part 2 starts. Considering the substantial literature requirement plus the cases and project work, we estimate that an extra 32h of study is needed, which is not included in the schedule.
Compulsory elements Project work and attendance at the project presentation is compulsory as well as work with two clinical cases. In the case of absence a separate occasion is organized with presentation for the course organizers. The web-based exam is mandatory.
Examination Web-based exam on the course content. Oral presentations of small-group project work. At this occasion special attention is given to that all students are actively participating. The clinical cases are examined by written reports.
Literature and other teaching material Abul Abbas and Andrew Lichtman: Basic Immunology. (Saunders Elsevier). The book is free and is handed out at the course start. Scientific review publications (specific state-of-the-art articles that are decided at course start)
Number of students 12 - 50
Selection of students Selection will be based on 1) the relevance of the course syllabus for the applicant's doctoral project (according to written motivation), 2) date for registration as a doctoral student (priority given to earlier registration date)
More information The course is divided into two sessions with 3 days of lectures each, January 16-18 and March 6-8 (Tuesday to Thursday). In between these days of lectures the students work on both a group project and an individual written assignment, including meetings with mentors and literature studies. Teachers include specialists in different fields of immunology including both basic and clinical researchers. We will use the Abbas ""Basic Immunology"" as the main course textbook, but literature also includes review papers, handouts etc. The texbook the book is free and is handed out at the course start. The course location is at the Department of Microbiology Tumor and Cell biology (MTC), Karolinska Institutet, Solna
Additional course leader The course is also given in the autumn by Jan Wahlström (MedS), course code #2302
Latest course evaluation Course evaluation report
Course responsible Lisa Westerberg
Institutionen för mikrobiologi, tumör- och cellbiologi

Lisa.Westerberg@ki.se
Contact person Mikael Karlsson
Institutionen för mikrobiologi, tumör- och cellbiologi

Mikael.Karlsson@ki.se


Lisa Westerberg
Institutionen för mikrobiologi, tumör- och cellbiologi

Lisa.Westerberg@ki.se