Course catalogue doctoral education - VT18

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Title Cellular Signalling
Course number 3049
Programme Utveckling och regeneration (DevReg)
Language English
Credits 1.5
Date 2018-03-19 -- 2018-03-23
Responsible KI department Institutionen för klinisk vetenskap, intervention och teknik
Specific entry requirements
Purpose of the course The purpose of the course is to give a broad view of various signalling pathways and enable to identify common themes on protein-protein and protein-lipid interactions. The students shall learn on how signal transduction occurs through a highly regulated cascade of events in side cells. The student should identify and reflect the knowledge (general methodology and theoretical concepts) gained with the benefit for own research.
Intended learning outcomes After the course, the student:

- should be able to show adaquate knowledge on current common methods and techniques, in the field of signal transduction.
- should be able to hold a journal club presentation in the field of signal transduction.
- should be able to apply some of the conceptual knowledge in his/her own research project(s).
Contents of the course The course brings up current aspects in cellular signalling and the developments in understanding the function of the different signalling pathways in various cell model systems. The course will cover major aspects of protein and lipid kinases, heterotrimeric G-proteins, small GTPases, cytokine and growth hormone receptors, secondary messengers, transcriptional regulation and signal transduction in cell specific responses to stimuli. In the context of the functional genomic era, the course will cover the molecular basis of certain diseases related to the abrogation of signalling pathways.
Teaching and learning activities Lectures, presentations and individual discussions with all participants. Students are encouraged to take up additional new topics with the course leader and lecturers. Discussions about resources to retrieve additional information about a particular issue within the field of signal transduction.
Compulsory elements All lectures and activity moments are compulsory, missing lectures must be compensated by written résumé, while activity moments should be taken again in the next course occasion.
Examination Oral Presentation is compulsory and it is essential to be an active participants in the discussions. It has to be shown that all the intended learning outcomes of the course are achieved.
Literature and other teaching material Recommended literature: 1. Review articles covering the lecture topics and/or the subject. 2. Gerhard Krauss "Biochemistry of Signal Transduction and Regulation" (2014), ISBN 978-3-527-33366-0, 5th edition, Wiley-VCH Verlag GmbH & Co. KGaA, Germany
Number of students 8 - 15
Selection of students Selection will be based on 1) the relevance of the course syllabus for the applicant's doctoral project (according to written motivation), 2) date for registration as a doctoral student (priority given to earlier registration date)
More information Time: Monday to Friday, 9:00 - 16:00; Location: Novum, Karolinska Institutet Campus Flemingsberg. The evaluation report below is from the same course last year, but with a different course number.
Additional course leader Hannes Olauson, Institutionen för klinisk vetenskap, intervention och teknik (CLINTEC):
Earlier evaluation of the course Evaluation report
Course responsible Anna Witasp
Institutionen för klinisk vetenskap, intervention och teknik
Contact person Anna Witasp
Institutionen för klinisk vetenskap, intervention och teknik