Kurskatalog forskarutbildning - VT18

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Titel Human embryonic stem cells
Kursnummer 2212
Program Utveckling och regeneration (DevReg)
Språk Engelska
Antal högskolepoäng 1.5
Datum 2018-05-14 -- 2018-05-18
Kursansvarig institution Institutionen för biovetenskaper och näringslära
Särskild behörighet
Kursens syfte The purpose of the course is to enable doctoral students to obtain a basic understanding of human reproductive biology with focus on human embryonic stem cell knowledge and cells replacement therapies and translational medicine. Experts in the field will provide a fresh overview of clinical and pre-clinical research aiming at development of novel treatment possibilities, but also discussing current limitations and general ethical aspects.
Finally the students will be enabled to improve their capacity to produce coherent, logical and concise explanations of data and concepts - both written and orally, through consideration of the course material.
Kursens lärandemål At the conclusion of this course students should be able to show a comprehensive view of:
- Pre implantation Embryology
- Derivation methods and culture conditions of hESCs
- Nutritional requirements of the blastocyst and stem cells
- Functional characteristics of different tissue culture incubators
- Characterization of the embryonic stem cells and the importance of the pluripotency of these cells and what is ongoing in this field
- Production of isogenics embryonic stem cells by somatic cell nuclear transfer (SCNT)
- The pluripotence induction of somatic cell by transduction (the iPS cells)
- Know the prospective possibilities of having a good culture system and be aware of potential development of hESC technology in the future.
- Be aware of the general aspects and implication of the stem cells research and the potentiality that these represent for clinical application.
Kursens innehåll 1. Embryology theory (lectures) 2. In vitro culture system (lectures) 3. Human Embryonic Stem cells culture (lectures) 4. Characterization of hESC (lectures) 5. Laboratory demonstrations 6. Genetics (lectures) 7. Introduction to different cell types (lectures) 8. Cell reprogramming (lectures) 9. Stem cells therapy and challenge today 10. Future in human embryonic stem cells (lecture) Course test, evaluation, discussions, examination and closing of course.
Arbetsformer Lectures and laboratory demonstrations.
Obligatoriska moment The laboratory parts are obligatory. If absent at laboratory activity; student should present a literature work related with the subject of the missing activity
Examination Written individual examination
Kurslitteratur och övriga läromedel Recommended literature: The Global politics of human embryonic stem cell science,Regenerative medicine transition, By, Herbert Gottwels, Brain Salter and Catherine Waldby, Publisher:Palgrave Mac Milan, 2009. Emerging technology platform for stem cells, edited by Uma lakshmipathy, Jonathan D. Chesnut.... Publisher: John Wiley & sons Ltd, 2009 Guidelines for human embryonic stem cell research, (Authors) Board of life sciences; National academy of sciences, Publisher: National academies press, 2005 Stem cell Research: Medical application & Ethical controversy, Joseph Panno, The New Biology, 2005 Human Embryology, William J. Larsen, Third Edition, Churchill Livinstone, 2001 Manipulating the mouse embryos "Laboratory manual" third edition Andras Nagy, Marina Gertsenstein, Kristina Vintersten, Richard Behringer, 2003 IVF LAB "Laboratory aspects of in-vitro fertilization" Editor: M. Bras, J.W. Lens, M. H. Piederiet, P.M. Rijinders, M. Verveld, G.H. Zeilmaker, 1996
Antal studenter 8 - 16
Urval av studenter Selection will be based on 1) the relevance of the course syllabus for the applicant's doctoral project (according to written motivation), 2) date for registration as a doctoral student (priority given to earlier registration date)
Övrig information The course will be held at Karolinska Institutet, Department of Biosciences and Nutrition, Novum Huddinge.
Ytterligare kursledare
Tidigare omdöme av kursen omdöme
Kursansvarig Jose Inzunza
Institutionen för biovetenskaper och näringslära
08-585 850 93
Jose.Inzunza@ki.se

Hälsovägen 7, Novum

141 86
Stockholm
Kontaktpersoner Jose Inzunza
Institutionen för biovetenskaper och näringslära
08-585 850 93
Jose.Inzunza@ki.se

Hälsovägen 7, Novum

141 86
Stockholm