Kurskatalog forskarutbildning - HT18

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Titel Biobanking as a resource for biomedical research
Kursnummer 2714
Program 0-Inte del av forskarutbildningsprogram
Språk Engelska
Antal högskolepoäng 1.5
Datum 2018-03-12 -- 2018-03-16
Kursansvarig institution Institutionen för medicinsk epidemiologi och biostatistik
Särskild behörighet Nej
Kursens syfte This course aims to provide practical knowledge to start biobanking with state of the art quality comprising ethics, legal aspects, sampling handling and logistics. Furthermore the course aims to enable the course participants to get insight in and knowledge about how to collect human tissue samples and associated data, about how to apply technology advancements such as next generation sequencing, proteomics and metabolomics to harness biological information from biobanked material such as tissues and liquid biopsies and finally to get insight into successful research projects where biobanking in combination with large scale analysis is having direct impact on health care. .
Kursens lärandemål At the end of the course the student should:
- Understand the value of biobanks and be able to explain how to use these rich sources of samples and related data.
- Understand the legal and ethical framework related to biobanks and how to utilize biobanked samples in future national and international projects,
- Have insight and knowledge about how to start a new study and understand the impact of quality and standardization on downstream applications,
- Understand and explain the need for a secure IT structure in order to ensure the sample donors integrity with a full traceability of samples and data,
- Discuss own or other's research projects related to biobanked samples.
Kursens innehåll 1. Practical knowledge to enable biobanking including - Ethical and Legal aspects - IT infrastructure - Required documentation and stakeholders - Biobank service; available infrastructures 2. How to biobank with high quality from various sources such as: - Blood/plasma/serum/urine - PBMC - Single cells - Tissues 3. Examples of how to apply molecular technologies to harness information - Proteomics of plasma and tissues - Metabolomics of plasma, serum and urine - Sequencing of circulating tumor DNA/RNA - Single cell sequencing of circulating tumor cells and tissues - DNA and RNA sequencing of tumor tissues - Epigenetics of blood and tissues 4. The value of applying quality registries to biobanked material
Arbetsformer - Lectures - Exercises - Field trip (visiting a biobank) - Final seminar with presentations and discussions about the course assignment (either a pre-defined biobank study or an example from own research)
Obligatoriska moment Taking part in all scheduled activities: lectures, field trip and presentation/examination. Compensation according to the instructions of the course director.
Examination Presentation and discussion of the course assignments, either a pre-defined biobank study or an example from own research. All learning outcomes will be covered.
Kurslitteratur och övriga läromedel Scientific articles that will be referred to during the course. Webpages: http://BBMRI-ERIC.eu/ http://www.isber.org/ https://www.scilifelab.se/ http://ki.se/kibiobank http://biobanksverige.se http://www.crb.uu.se/om-crb/
Antal studenter 15 - 25
Urval av studenter Selection will be based on 1) the relevance of the course syllabus for the applicant's doctoral project (according to written motivation), 2) date for registration as a doctoral student (priority given to earlier registration date).
Övrig information Monday - Friday 9:00-16:00 Venue: Wargentin, Dept of medical epidemiology and biostatistics, Campus Solna.
Ytterligare kursledare Johan Lindberg.
Tidigare omdöme av kursen omdöme
Kursansvarig Gunnel Tybring
Institutionen för medicinsk epidemiologi och biostatistik

Gunnel.Tybring@ki.se
Kontaktpersoner Johan Lindberg
Institutionen för medicinsk epidemiologi och biostatistik

johan.lindberg@ki.se