Course catalogue doctoral education - HT18

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Title Translational Paediatric Oncology in the Era of Immunotherapy and Omics
Course number 3022
Programme Tumor Biology and Oncology (FoTO)
Language English
Credits 1.5
Date 2018-04-23 -- 2018-04-27
Responsible KI department Department of Women's and children's health
Specific entry requirements
Purpose of the course - To enable to obtain a comprehensive overview of the different domains within childhood cancer research and to understand the historical milestones forming the paradigms that have led to a cure of 8 out of 10 children with cancer
- To give an insight into the current limitations and problems of childhood cancer treatment
- To enable to get an understanding of how new methodologies in molecular biology increase our knowledge about tumourigenesis and tumour evolution.
- To provide an opportunity to hypothesise and develop ideas about how to cure the remaining 2 out of 10 children with cancer.
Intended learning outcomes At the end of the course the students should be able to:

- Summarise the basic epidemiological data, tumor biology and genetics, novel therapy modalities like targeted therapies and immunotherapy, including side effects, late effects and follow up within the field of paediatric oncology.
- Discuss the ethical issues around childhood cancer research.
- Describe and understand the principles of treatment, existing therapies, new targeted therapies and personalized medicine.
- Explain and theorize about the link between cancer cell biology, tumour microenvironment, immunology, genetics, and drug treatments - current and development of new drugs.
- Understand and discuss the current experimental methodology applied to pediatric oncology research such as in vivo, in vitro and in silico models.
- Critical comment on research findings regarding paediatric oncology research.
Contents of the course Introduction to research on paediatric oncology for PhD students and junior postdocs, with research projects in this specific area or in an adjacent area. The students will be presented with and will discuss problems, possibilities, and research models that are specific for the research area of paediatric oncology. The course will provide a general introduction to the field and focus on distinct, but interconnected topics specific for paediatric oncology, namely ethics, epidemiology, tumor biology and genetics, existing and novel targeted drug treatments as well as immunotherapy, and side effects, late effects and follow up. The last day will be dedicated to a symposium with invited lecturers that are internationally renowned expert in their fields.
Teaching and learning activities Lectures, seminars, group exercises with supervised discussions. To promote active discussion and participation, each student will prepare a poster and a short oral presentation on their current or intended research to be submitted no later than two weeks before the course start. The course will be complemented with a one-day research mini symposium.
Compulsory elements All course activities are compulsory. Absence can be compensated for by other activities in agreement with the course leaders.
Examination To pass the course the students must show that they have reached the learning outcomes of the course. Each students should prepare a scientific poster on an actual or hypothetical childhood cancer research project, including one of the following topics: epidemiology, register research, tumour biology and genetics, novel therapy modalities like targeted therapies and immunotherapy, and give an oral presentation of the poster and answer to critical questions of the audience consisting of the course leaders and course participants. Each participant in the course needs to be able not only to answer questions in a satisfactory way but also to raise relevant questions and to be able to discuss in line with the intended learning outcomes of the course.
Literature and other teaching material Current review articles, at least two on each topic (sent to the students in advance), in addition distributed material, including articles and book chapters.
Number of students 8 - 28
Selection of students Priority will be given to registered doctoral students with projects concerning pediatric oncology research who are in the later phase of their doctoral education. Thereafter student in an earlier phase will be prioritized while acceptance of post docs will be subjected to availability.
More information Monday to Thursday are organized as full days with lectures, seminars and discussions. The course concludes with a symposium on Friday with several known experts in the field. The course will be held at Cancer Centre Karolinska (CCK) and the Astrid Lindgren Children's Hospital (exact rooms will be announced in due time). The symposium will take place at the Nobel Forum.
Additional course leader Anna Nilsson, MD, PhD, docent Nikolas Herold, MD, Dr. med. Malin Wickström Näsman, PhD Désirée Gavhed, PhD Per Kogner, MD, PhD, professor
Earlier evaluation of the course Not available
Course responsible Anna Nilsson
Department of Women's and children's health

Anna.Nilsson.1@ki.se
Contact person Désirée Gavhed
Institutionen för kvinnors och barns hälsa

Desiree.Gavhed@ki.se


Nikolas Herold
Institutionen för kvinnors och barns hälsa

nikolas.herold@ki.se


Malin Wickström
Institutionen för kvinnors och barns hälsa
08-51772989
Malin.Wickstrom@ki.se


Teresa Frisan
Institutionen för cell- och molekylärbiologi
08-52486385
Teresa.Frisan@ki.se

Berzelius väg 35

S-17177
Stockholm