Kurskatalog forskarutbildning - HT18

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Titel Applied longitudinal data analysis
Kursnummer 2798
Program Epidemiologi
Språk Engelska
Antal högskolepoäng 2.5
Datum 2017-09-05 -- 2017-09-13
Kursansvarig institution Institutionen för medicinsk epidemiologi och biostatistik
Särskild behörighet Knowledge in epidemiology and biostatistics equivalent to "Epidemiology I: Introduction to epidemiology", "Biostatistics I: Introduction for epidemiologists" and "Biostatistics II: Logistic regression for epidemiologists" or corresponding courses.
Kursens syfte The course gives an introduction to modern methods for the analysis of longitudinal and repeated measures studies which are commonly used in epidemiological studies and in clinical trials.
Kursens lärandemål After successfully completing this course you as a student are expected to be able to:

- Describe the statistical methods utilized to analyze longitudinal data in a variety of settings and with a variety of types of outcome variables.

- Analyze a scientific problem that requires repeated measurements, identify an appropriate design, and identify the statistical methods required to analyze the data.

- Utilize statistical software (e.g., Stata) to perform longitudinal analyses of data generated from randomized and observational studies with repeated measures designs.

- Apply modern methods for the analysis of longitudinal data to a range of settings encountered in biomedical and public health research.

- Interpret and communicate the clinical/scientific meaning of the results of a longitudinal analysis.

Intended learning outcomes are classified according to Bloom¿s taxonomy: knowledge, comprehension, application, analysis, synthesis, and evaluation (Bloom, 1956, extended by Anderson and Krathwohl, 2001).
Kursens innehåll The course gives an introduction to modern methods for the analysis of longitudinal and repeated measures studies which are commonly used in epidemiological studies and in clinical trials. The defining feature of a longitudinal study is that measurements of the response are taken repeatedly through time on the same individuals. The primary goal of a longitudinal study is to characterize an outcome (and potentially change in that outcome over time) and the factors that influence the outcome (and its change). A feature of longitudinal data that complicates analysis is the positive correlation (i.e., lack of independence) among repeated observations and possible heterogeneity of variability across measurement occasions. The course covers the following topics: Introduction to longitudinal data, notation for correlated data, modeling the mean response (analysis of response profiles, parametric and semi-parametric trends), modeling the covariance, growth curves (trajectories), fixed effects models, and mixed effects models (that include random effects). This course is focused on general regression models for longitudinal data when the response variable is either continuous (linear models) or discrete (e.g., binary or count data that require logistic and Poisson models). Topics covered in the course will include: introduction to generalized linear models (e.g., linear, logistic, and Poisson regression), extensions of generalized linear models to longitudinal data, marginal models and generalized estimating equations (GEE), random effects models for continuous and categorical data (generalized linear mixed models), and contrasting marginal and mixed effects models. The course is intended for all students interested in epidemiology, biostatistics and public health.
Arbetsformer Lectures, computer lab with exercises focusing on analysis of real data sets using statistical software (Stata), group discussions, literature review.
Obligatoriska moment The individual written examination (summative assessment).
Examination To pass the course, the student has to show that the learning outcomes have been achieved. Assessments methods used are group assignments (formative assessments) and an individual written take-home examination (summative assessment). The focus will be on understanding concepts and their application to analysis of epidemiological studies, rather than mathematical detail. The examination is viewed as a contributing to the development of knowledge, rather than as a test of knowledge. Students who do not obtain a passing grade in the first examination will be offered a second examination within two months of the final day of the course. Students who do not obtain a passing grade at the first two examinations will be given top priority for admission the next time the course is offered. If the course is not offered during the following two academic terms, a third examination will be scheduled within 12 months of the final day of the course.
Kurslitteratur och övriga läromedel Recommended reading: Fitzmaurice GM, Laird NM, Ware JH. Applied Longitudinal Analysis, 2nd Ed. Wiley & Sons, 2011 PDF course notes of some chapters of prospective book Jewell NP, Hubbard A, Heggeseth, B, Analysis of Longitudinal Studies in Epidemiology (to be distributed)
Antal studenter 8 - 25
Urval av studenter Eligible doctoral students, with required prerequisite knowledge, will be selected based on 1) the relevance of the syllabus for the applicant's doctoral project (according to written motivation), and 2) date for registration as doctoral student (priority given to earlier registration date). To be considered, submit a completed application form. Give all information requested, including a description of current research and motivation for attending, and an account of previous courses taken.
Övrig information Course dates are September 5, 6, 7, 8, 11, 12 and 13.
Ytterligare kursledare Course leader is Nicholas P. Jewell PhD, Professor of Biostatistics and Statistics, UC Berkeley, School of Public Health Biostatistics Division & Department of Statistics, California, USA
Tidigare omdöme av kursen omdöme
Kursansvarig Rino Bellocco
Institutionen för medicinsk epidemiologi och biostatistik



Kontaktpersoner Gunilla Nilsson Roos
Institutionen för medicinsk epidemiologi och biostatistik
08-524 822 93