Course catalogue doctoral education - HT17

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Title Preclinical Imaging Techniques
Course number 2987
Program Tumörbiologi och onkologi (FoTO)
Language English
Credits 1.5
Date 2017-11-20 -- 2017-11-24
Responsible KI department Institutionen för laboratoriemedicin
Specific entry requirements Students must have passed the courses in laboratory animal science: Function A - Rodents and lagomorphs before attending this course.
Purpose of the course The purpose of the course is to provide an overview on state-of-the-art small animal imaging techniques including fluorescence imaging, bioluminescence imaging, ultrasound, photoacoustic imaging, computed tomography (CT), magnetic resonance imaging (MRI) and Positron Emission Tomography (PET). The course will cover (1) basic theory and instrumentation principles of various imaging modalities, (2) applications of small animal imaging in translational research, (3) multi-modality imaging and co-registration for accurate diagnostic and follow-up of treatment efficacy and (4) hands-on training in imaging acquisition, imaging analysis and imaging reconstruction.
Learning outcomes The intended learning outcome will be that at the end of the course, the student is expected to:
(1) understand the basic concepts and outcomes of the different imaging modalities;
(2) gain the knowledge and practical experience to run small animal imaging with various techniques;
(3) process and analyze imaging data;
(4) to run multi-modality imaging, evaluate data and co-registration;
(5) be able to choose the right imaging modality, animal models and design for the animal experiment in preclinical studies in their own research field.
Contents of the course This course will fully cover the background, theory and principles underlying each imaging modality used in preclinical imaging, with extensive practical training in the lab. There will be a general introduction to all the different imaging modalities including theory, principle of concept and application in research. For each modality, students will be introduced to theory and instrumental principles, experimental design in different research areas, research project case study and critical review. In the hands-on sessions, students will have the opportunity to acquire images in different animal models and to use several kinds of software to process imaging analysis, imaging reconstruction and co-registration.
Teaching and learning activities Lectures/seminars, group discussions, critical review literature studies, and hands-on training.
Compulsory elements The individual assignment, as well as attendance during the theoretical and hands-on parts of the course, is compulsory.
Examination The intended learning outcomes will be assessed by individual assignment. The individual assignment is to describe a research project in the student's own research area utilizing the small animal imaging techniques introduced during the course. In the assignment, students are required to describe detailed experimental design, rationale behind the experimental design and methodology in data acquisition/analysis. Students must complete the assignment by the end of the course. Students who do not obtain a passing grade in the first examination will be offered a second examination within two weeks of the final day of the course. The examination includes a written report of 1-2 pages and oral presentation.
Literature and other teaching material Small animal imaging: basic and practical guide. Fabian Kiessling, Bernd J. Pichler. 2011. Springer-Verlag Berlin Heidelberg. ISBN 978-3-642-12945-2. DOI 10.1007/978-3-642-12945-2.
Number of students 10 - 20
Selection of students Selection will be based on 1) the relevance of the course syllabus for the applicant's doctoral project (according to written motivation), 2) date for registration as a doctoral student (priority given to earlier registration date)
More information The course will be held Monday Through Friday, approximately 8:30-17:00. More exact information regarding the schedule and venue will be sent to the course participants well ahead of time.
Course directors
Earlier evaluation of the course Not available
Course responsible Moustapha Hassan
Institutionen för laboratoriemedicin
08-585 838 62
Moustapha.Hassan@ki.se
Contact person Jennifer Usterud
Institutionen för laboratoriemedicin
08-585 832 38
jennifer.usterud@ki.se