Course catalogue doctoral education - HT17

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Title Mechanisms in regulation of development and function of the blood- and lymph- vasculature
Course number 2989
Program Kardiovaskulär forskning
Language English
Credits 1.5
Date 2017-10-23 -- 2017-10-27
Responsible KI department Institutionen för medicinsk biokemi och biofysik
Specific entry requirements
Purpose of the course To educate course participants in the mechanisms that control vascular morphogenesis and function in development, physiology and various pathologies. To stimulate understanding of how developmental aspects/models can be applied to understand human disease. To give the participants a clear view on the advantages and potential drawbacks with transgenic technologies in the study of vascular biology. To present recent conceptual advances in the field as well as future challenges and promises. Altogether this will provide insight on the relation between defective function at the single cell level and systemic alteration.
Learning outcomes After completing the course, the doctoral student should:
-Be able to discuss central concepts in vascular biology related to blood/lymph vessel formation and function.
-Be able to discuss vascular mechanisms in cardiovascular disease, including stroke, and their risk factors.
-Be able to discuss the principles of common methods used in vascular biology research and evaluate the advantages and disadvantages of using these techniques.
Contents of the course This course will cover: -Basic and molecular principles of how blood/lymph vessels develop, are remodeled and are functionally integrated with the surrounding tissue. -The role of blood/lymph vessels in various pathological conditions with emphasis on cardiovascular disease. -Discussion on recent targeting strategies in cardiovascular-related disease. -Scientific methods and experimental model systems that are commonly used to study vascular mechanisms in normal and pathological conditions.
Teaching and learning activities The theoretical part of the course includes lectures, group discussions and project work presentations. The practical part of the course includes demonstrations of common vascular model systems (e.g. retina preparations) and advanced imaging technologies (in vivo live imaging using two-photon confocal microscopy).
Compulsory elements Project work presentations are mandatory. In the case of motivated absence during presentations a written report covering the topic of the group presentation has to be submitted to the course leaders who will evaluate the work and either approve, or in the case of insufficient quality, ask for revision.
Examination To pass the course, a participant has to: -actively participate in the discussions during the course -present their project work -demonstrate an understanding of scientific perspectives of basic vascular biology research
Literature and other teaching material Subject-specific literature (relevant and uptodate high-quality scientific papers) will be distributed during the introduction to the course.
Number of students 8 - 20
Selection of students Selection will be based on 1) the relevance of the course syllabus for the applicant's doctoral project (according to written motivation), 2) date for registration as a doctoral student (priority given to earlier registration date)
More information Scheeles väg 2, Solna
Course directors Additional course leader: Linda.Fredriksson@ki.se
Earlier evaluation of the course Not available
Course responsible Lars Jakobsson
Institutionen för medicinsk biokemi och biofysik

Lars.Jakobsson@ki.se
Contact person Daniel Nyqvist
Institutionen för medicinsk biokemi och biofysik

daniel.nyqvist@ki.se


Linda Fredriksson
Institutionen för medicinsk biokemi och biofysik

linda.fredriksson@ki.se