Course catalogue doctoral education - VT18

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Title The developing brain
Course number 2780
Program Neurovetenskap
Language English
Credits 1.5
Date 2017-08-28 -- 2017-09-01
Responsible KI department Institutionen för medicinsk biokemi och biofysik
Specific entry requirements
Purpose of the course Developmental biology lies at the heart of an effort to understanding complex biological systems. By studying how neural circuits are assembled we can extrapolate key aspects of their function as well as devise strategies for their repair. This course is given to deepen the understanding of how molecular and cellular mechanisms underlie neurobiological function and to widen the horizon of students within the strong Karolinska neuroscience community.
Learning outcomes By the end of the course the student shall be able to describe the major steps contributing to the development of the nervous system and transfer new knowledge acquired in the course into their specific projects or fields of research.
Contents of the course The course will cover the main steps of development from neural stem cells to mature circuits, including the patterning of the neural plate and thus the origin of cell types, the interplay between intrinsic and extrinsic factors, gene regulation including epigenetics, neuro-glia interactions and the role of network activity in shaping the final circuits. Different molecular and tracing technologies, and model organisms will be covered. An important aspect of the course regards molecular technologies for labeling, transcriptional analysis and genetic manipulation of defined neural populations. Connections between aberrant developmental processes and neurological disorders will be discussed.
Teaching and learning activities Lectures by invited international experts, group work and seminar presentations.
Compulsory elements All lectures and the seminar presentation (examination) are compulsory.
Examination The students should demonstrate their knowledge about the intended learning outcomes stated above including reflect on which aspects are relevant for their own research in a seminar presentation and in discussions.
Literature and other teaching material Relevant original research papers and review papers will be provided by the course organizers as recommended reference literature.
Number of students 10 - 25
Selection of students Selection will be based on 1) the relevance of the course syllabus for the applicant's doctoral project (according to written motivation), 2) date for registration as a doctoral student (priority given to earlier registration date).
More information The course will be held at lecture fall "Tellus" at Scheeles väg 2, 5th floor. It is a full time course and schedule will be sent out after acceptance to the course. For an in depth understanding of the connection between brain development and clinical aspects of cognitive disorders, Course 2605 is recommended.
Additional course leader The course is given by three course leaders: Gonçalo Castelo-Branco, Jens Hjerling-Leffler and Ulrika Marklund all att MBB.
Earlier evaluation of the course Evaluation report
Course responsible Jens Hjerling-Leffler
Institutionen för medicinsk biokemi och biofysik

jens.hjerling-leffler@ki.se
Contact person Goncalo Castelo-Branco
Institutionen för medicinsk biokemi och biofysik

Goncalo.Castelo-Branco@ki.se


Ulrika Marklund
Institutionen för medicinsk biokemi och biofysik

Ulrika.Marklund@ki.se