Course catalogue doctoral education - HT17

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Title Adverse outcome pathways (AOPs)-principles and applications in toxicology and health risk assessment
Course number 2986
Program Miljöfaktorer och hälsa
Language English
Credits 1.5
Date 2017-11-06 -- 2017-11-10
Responsible KI department Institutet för miljömedicin
Specific entry requirements
Purpose of the course The purpose of the course is to enable the acquirement of knowledge and understanding in how the concept of Adverse outcome pathways (AOPs) can provide a framework for research in toxicology and for applications for health risk assessment. An AOP is a description of a sequence of events starting with the interaction of a chemical with a biomolecule in a target cell or tissue (molecular initiating event), progressing through key events and ending in an adverse outcome.
Learning outcomes At the end of the course the student should be able to:
describe the principles and components of Adverse Outcome Pathways (AOPs)
explain how experimental studies can support the development of AOPs
discuss how AOPs can be used as a central framework for mechanistic toxicity studies, toxicity testing and health risk assessment
Contents of the course The course will include the concept and principles of Adverse Outcome Pathways (AOPs). Development and assessment of AOPs. Examples of different AOPs. Application of the AOP concept in toxicological research and health risk assessment.
Teaching and learning activities Teaching and learning activities include lectures, exercises and group assignments.
Compulsory elements Participation in the exercises and group assignments is compulsory. Absence can be compensated with an individual task.
Examination Examination is in the form of a written assignment and/or oral presentation.
Literature and other teaching material Scientific publications and reports from international organisations.
Number of students 8 - 14
Selection of students Selection will be based on 1) the relevance of the course syllabus for the applicant's doctoral project (according to written motivation), 2) date for registration as a doctoral student (priority given to earlier registration date)
More information The course is held at KI Campus Solna
Course directors Course directors: Johanna Zilliacus and Annika Hanberg, Institute of Environmental Medicine (IMM), Karolinska Institutet.
Earlier evaluation of the course Not available
Course responsible Johanna Zilliacus
Institutet för miljömedicin
08 52483544
Johanna.Zilliacus@ki.se
Contact person Johanna Bergman
Institutet för miljömedicin

johanna.bergman@ki.se

Nobels väg 13

17177
Stockholm