Course catalogue doctoral education - VT18

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Title Antigen presentation and T cell activation
Course number 2363
Program Allergi, immunologi och inflammation (Aii)
Language English
Credits 1.5
Date 2017-11-20 -- 2017-11-24
Responsible KI department Institutionen för onkologi-patologi
Specific entry requirements Basic immunology course, or otherwise have attained the same level of previous knowledge.
Purpose of the course This course will provide a cutting edge overview of antigen presentation and T cell activation. This course is suitable for PhD students with basic immunology knowledge who want to deepen their knowledge in important aspects of various lymphocyte subsets biology. Students will also learn about new techniques such as lymphocyte visualization and functional assays that could be beneficial for their own research projects.
Learning outcomes By completing this course the students will be able to account for different types of antigen capture and processing, antigen presentation pathways (MHC class I and II), the MR1 and CD1 system, peptide/lipid/glycolipid presentation as well as T-cell subsets and invariant lymphocytes.
Students will also be able to demonstrate that they have acquired the required knowledge about T lymphocyte recognition of antigen-presentation with strong focus on lymphocyte and target cell. The students will also be able to demonstrate that they have acquired the required knowledge about T-cell activation and the effects of this in steady state or disease as well as in cell therapy.
Contents of the course The following will be covered during the course: Antigen capture (including endocytosis, phagocytosis) and some immune evasion strategies related to this. This will be followed by a thorough walk-through of the antigen presentation pathways, both MHC class I and II, and upstream and downstream TCR activation. The CD1 system, presentation of lipids, glycolipids (including microbial interference, presentation to lymphocytes such as CD1 restricted T cells and NKT cells, lymphocyte mediated regulation of antigen presentation), MR1 presentation and MAIT cell activation will be discussed. Manipulation of T cell activation by checkpoint inhibitors, and practical applications such as vaccination and immunotherapy will also be covered. New techniques and assays to analyze T cell activation will be presented.
Teaching and learning activities The course will be based on lectures, as well as extra time for follow up discussions. In addition a smaller group work will enable the students to gain deeper knowledge in a small area of interest. The students are also given literature (see below) in order to prepare for the lectures and discussions.
Compulsory elements All lectures and group sessions are considered mandatory. Missed events should be compensated for with a written report on the subject in accordance with the indications of the course organizer.
Examination To pass the course, the student has to show that the learning outcomes have been reached. The students will be assessed with a group project presented in a written report, along with individual oral presentations. The focus of the examination is gain of knowledge rather than test of knowledge.
Literature and other teaching material Review articles and selected articles relevant to the lectures (invited speakers will also be asked to suggest papers), will be distributed prior to the course. Examples: - T cell antigen receptor recognition of antigen-presenting molecules. Annu Rev Immunol. 2015;33:169-200. Rossjohn et al.; - The burgeoning family of unconventional T cells. Nat Immunol. 2015 Nov;16(11):1114-23.Godfrey DI et al.; - Early T cell activation: integrating biochemical, structural, and biophysical cues. Annu Rev Immunol. 2015;33:539-61.Malissen B.
Number of students 14 - 22
Selection of students Selection will be based on 1) the relevance of the course syllabus for the applicant's doctoral project (according to written motivation), 2) date for registration as a doctoral student (priority given to earlier registration date).
More information The course takes place at Karolinska University hospital in Huddinge.
Additional course leader
Earlier evaluation of the course Evaluation report
Course responsible Sarah Thunberg
Institutionen för onkologi-patologi

sarah.thunberg@ki.se
Contact person Isabelle Magalhaes
Institutionen för onkologi-patologi

Isabelle.Magalhaes@ki.se